Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Oct 24, 2023; 14(10): 373-399
Published online Oct 24, 2023. doi: 10.5306/wjco.v14.i10.373
Comprehensive analysis of disulfidptosis related genes and prognosis of gastric cancer
Qian Li, Long-Kuan Yin
Qian Li, Department of Oncology, Fushun Hospital of Traditional Chinese Medicine, Zigong 643200, Sichuan Province, China
Long-Kuan Yin, Department of Gastrointestinal Surgery, Fushun People’s Hospital, Zigong 643200, Sichuan Province, China
Author contributions: Li Q contributed to this work; Yin LK and Li Q prepared for the figures and tables; and all authors have approved the final manuscript.
Institutional review board statement: The data supporting the results of this study are available from Gene Expression Omnibus database (GSE84433andGSE26253) and the expression data, clinical data, mutation data, and copy data related to gastric cancer from The Cancer Genome Atlas database.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Long-Kuan Yin, Doctor, Researcher, Department of Gastrointestinal Surgery, Fushun People’s Hospital, No. 490 Jixiang Road, Fushi Town, Zigong 643200, Sichuan Province, China. 782286066@qq.com
Received: July 30, 2023
Peer-review started: July 30, 2023
First decision: August 24, 2023
Revised: September 7, 2023
Accepted: September 18, 2023
Article in press: September 18, 2023
Published online: October 24, 2023
Processing time: 85 Days and 17.5 Hours
Core Tip

Core Tip: Gastric cancer (GC) is a common malignant tumor of the digestive system. Disulfidptosis is a new programmed cell death mechanism. The specific mechanism of disulfidptosis in GC is not fully understood. This study found that the disulfidptosis related gene may be related to the prognosis of gastric cancer. PLS3, GRP, APOD, SGCE, COL8A1, VAMP7, these six genes constitute a predictive model for gastric cancer prognosis. APOD is a potential therapeutic target. Bosutinib and other drugs are sensitive for the treatment of gastric cancer.