Clinical and Translational Research
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2022; 13(8): 675-687
Published online Aug 24, 2022. doi: 10.5306/wjco.v13.i8.675
Eight hub genes as potential biomarkers for breast cancer diagnosis and prognosis: A TCGA-based study
Nan Liu, Guo-Duo Zhang, Ping Bai, Li Su, Hao Tian, Miao He
Nan Liu, Guo-Duo Zhang, Ping Bai, Li Su, Miao He, Department of Hematology and Oncology, Chongqing Traditional Chinese Medicine Hospital, Chengdu University of Traditional Chinese Medicine, Chongqing 400011, China
Hao Tian, Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China
Author contributions: Liu N performed the experiment and wrote the paper; Liu N, Zhang GD, and Bai P contributed to the bioinformatics analysis and figure preparation; Tian H and Su L modified the structure and language of the manuscript; He M and Tian H contributed to the conception and design of the study and the revisions of the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: Not applicable.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Miao He, MS, Department of Hematology and Oncology, Chongqing Traditional Chinese Medicine Hospital, Chengdu University of Traditional Chinese Medicine, Daomenkou 40, Chongqing 400011, China. zhuytzhuzh@163.com
Received: August 2, 2021
Peer-review started: August 2, 2021
First decision: November 6, 2021
Revised: December 23, 2021
Accepted: July 26, 2022
Article in press: July 26, 2022
Published online: August 24, 2022
Processing time: 386 Days and 8.1 Hours
Core Tip

Core Tip: This study identified 1317 DEGs related to the occurrence and development of breast cancer (BC), 165 DEGs related to prognosis, and 8 hub genes (MAD2L1, PLK1, SAA1, CCNB1, SHCBP1, KIF4A, ANLN, and ERCC6L). Each of these eight hub genes has different expression levels in BC and is significantly related to prognosis. The results of this study indicate that studying these DEGs may help provide a full understanding of the molecular mechanisms underlying BC pathogenesis and progression. Moreover, these hub genes may serve as potential prognostic markers and therapeutic targets, which provide a reference for more in-depth and extensive prospective clinical research.