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World J Clin Oncol. Oct 24, 2022; 13(10): 762-778
Published online Oct 24, 2022. doi: 10.5306/wjco.v13.i10.762
Systems biology and OMIC data integration to understand gastrointestinal cancers
Iasmin Moreira Costa Bispo, Henry Paul Granger, Palloma Porto Almeida, Patricia Belini Nishiyama, Leandro Martins de Freitas
Iasmin Moreira Costa Bispo, Henry Paul Granger, Patricia Belini Nishiyama, Leandro Martins de Freitas, Núcleo de Biointegração, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45.029-094, Bahia, Brazil
Palloma Porto Almeida, Division of Experimental and Translational Research, Brazilian National Cancer Institute, Rio de Janeiro 20231-050, Brazil
Author contributions: Bispo IMC, Granger HP, and de Freitas LM wrote the paper; Almeida PP collected the data and contributed to the analyses; Nishiyama PB and de Freitas LM revised the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Leandro Martins de Freitas, BSc, MSc, PhD, Professor, Núcleo de Biointegração, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Rio de Contas, 58, Bairro Candeias, Vitória da Conquista 45.029-094, Bahia, Brazil. leandromartins@ufba.br
Received: March 16, 2021
Peer-review started: March 16, 2021
First decision: April 27, 2021
Revised: May 22, 2021
Accepted: October 2, 2022
Article in press: October 2, 2022
Published online: October 24, 2022
Processing time: 583 Days and 6.1 Hours
Core Tip

Core Tip: We highlight the genomic mutations and cellular pathways in gastrointestinal (GI) cancers. These are responsible for the cell’s behavior, allowing unlimited cell replication and invasion of other tissues. Using the STRING database, we found that Akt1, catenin beta 1, E1A binding protein p300, tumor protein p53 (TP53), and TP53 binding protein 1 are central nodes in the GI cancer protein network. Their expression is associated with poor survival in some GI cancers, which was confirmed by the Kaplan Meier plotter database. This information points to crucial and shared aspects of the most frequent GI cancers.