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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2021; 12(9): 725-745
Published online Sep 24, 2021. doi: 10.5306/wjco.v12.i9.725
Metastatic disease to the liver: Locoregional therapy strategies and outcomes
Kylie E Zane, Jordan M Cloyd, Khalid S Mumtaz, Vibhor Wadhwa, Mina S Makary
Kylie E Zane, Mina S Makary, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Jordan M Cloyd, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Khalid S Mumtaz, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Vibhor Wadhwa, Department of Radiology, Weill Cornell Medical Center, New York City, NY 10065, United States
Author contributions: Zane KE, Cloyd JM, Mumtaz K, Wadhwa V, and Makary MS performed the literature review, wrote the manuscript, prepared the tables, made the requested revisions, and provided final approval of the final version of the manuscript to be published.
Conflict-of-interest statement: There are no conflict of interests associated with any of the authors of this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mina S Makary, MD, Assistant Professor, Attending Doctor, Director, Department of Radiology, The Ohio State University Wexner Medical Center, 4th Floor Faculty Office Tower, Columbus, OH 43210, United States. mina.makary@osumc.edu
Received: April 2, 2021
Peer-review started: April 2, 2021
First decision: June 7, 2021
Revised: June 14, 2021
Accepted: August 31, 2021
Article in press: August 31, 2021
Published online: September 24, 2021
Processing time: 168 Days and 6.5 Hours
Core Tip

Core Tip: Locoregional percutaneous catheter-directed approaches have been associated with better tumor response, improved disease-free and overall survival, and decreased morbidity in metastatic disease to the liver compared to standard treatment. This review explores recent advances in liver-directed therapies for metastatic liver disease from primary colorectal, neuroendocrine, breast, and lung cancer, as well as uveal melanoma, cholangiocarcinoma, and sarcoma. Therapies discussed include bland transarterial embolization, chemoembolization, radioembolization, and ablative therapies, with a focus on current treatment approaches, outcomes of locoregional therapy, and future directions in each type of metastatic disease.