Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2021; 12(8): 623-645
Published online Aug 24, 2021. doi: 10.5306/wjco.v12.i8.623
Liver transplantation in malignant disease
Sven Arke Lang, Jan Bednarsch, Zoltan Czigany, Katharina Joechle, Andreas Kroh, Iakovos Amygdalos, Pavel Strnad, Tony Bruns, Daniel Heise, Florian Ulmer, Ulf Peter Neumann
Sven Arke Lang, Jan Bednarsch, Zoltan Czigany, Katharina Joechle, Andreas Kroh, Iakovos Amygdalos, Daniel Heise, Florian Ulmer, Ulf Peter Neumann, Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen 52074, Germany
Pavel Strnad, Tony Bruns, Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen 52074, Germany
Author contributions: Lang SA contributed to conception and design, acquisition of data, drafting the article, critical revision for important content, and final approval of the article; Neumann UP contributed to conception and design, critical revision and final approval; Ulmer F, Heise D, Bruns T, Strnad P contributed to critical revision and final approval; Bednarsch J, Czigany Z, Joechle K, Amygdalos I contributed to critical revision, data acquisition and final approval.
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sven Arke Lang, FEBS, MD, Professor, Surgeon, Department of Surgery and Transplantation, University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany. svlang@ukaachen.de
Received: February 24, 2021
Peer-review started: February 24, 2021
First decision: May 7, 2021
Revised: June 15, 2021
Accepted: July 23, 2021
Article in press: July 23, 2021
Published online: August 24, 2021
Processing time: 179 Days and 21.7 Hours
Core Tip

Core Tip: This review focuses on the role of liver transplantation in the treatment of primary and secondary liver cancer. Particularly, we summarize the selection criteria for hepatocellular carcinoma and the available evidence for liver transplantation in perihilar and intrahepatic cholangiocarcinoma. Very rare indications such as hepatic epithelioid hemangioendothelioma, fibrolamellar carcinoma, hepatic angiosarcoma and undifferentiated embryonal sarcoma of the liver are reviewed. In secondary liver cancer, neuroendocrine liver metastases constitute the only established indication so far, and the existing data is recapitulated. Regarding colorectal liver metastases, current novel evidence and ongoing studies are summarized.