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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2021; 12(12): 1193-1201
Published online Dec 24, 2021. doi: 10.5306/wjco.v12.i12.1193
Published online Dec 24, 2021. doi: 10.5306/wjco.v12.i12.1193
Role of liver transplantation in the management of colorectal liver metastases: Challenges and opportunities
Panagiotis T Tasoudis, School of Health Sciences, University of Thessaly, Larissa 41500, Greece
Ioannis A Ziogas, Sophoclis P Alexopoulos, Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN 37232, United States
John J Fung, Department of Surgery, University of Chicago Medicine Transplant Institute, Chicago, IL 60637, United States
Georgios Tsoulfas, Department of Transplant Surgery, Aristotle University School of Medicine, Thessaloniki 54622, Greece
Author contributions: Tasoudis PT and Ziogas IA wrote the paper; Alexopoulos SP, Fung JJ, Tsoulfas G critically revised the manuscript for important intellectual content.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Georgios Tsoulfas, FACS, FICS, MD, PhD, Associate Professor, Department of Transplant Surgery, Aristotle University School of Medicine, 66 Tsimiski Street, Thessaloniki 54622, Greece. tsoulfasg@gmail.com
Received: June 23, 2021
Peer-review started: June 23, 2021
First decision: July 27, 2021
Revised: June 27, 2021
Accepted: November 26, 2021
Article in press: November 26, 2021
Published online: December 24, 2021
Peer-review started: June 23, 2021
First decision: July 27, 2021
Revised: June 27, 2021
Accepted: November 26, 2021
Article in press: November 26, 2021
Published online: December 24, 2021
Core Tip
Core Tip: Despite the discouraging results of the previous decades, reports from the recent era showed promising results and reemerged the idea of liver transplantation (LT) for colorectal liver metastases (CRLM). Documentation of patient selection criteria and stronger evidence from ongoing prospective trials may reinforce the implementation of LT as an oncologic treatment for CRLM.