Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2021; 12(12): 1169-1181
Published online Dec 24, 2021. doi: 10.5306/wjco.v12.i12.1169
Published online Dec 24, 2021. doi: 10.5306/wjco.v12.i12.1169
Detection of circulating tumour cells in colorectal cancer: Emerging techniques and clinical implications
Alka Yadav, Ashok Kumar, Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Mohammad Haris Siddiqui, Department of Bioengineering, Integral University, Lucknow 226026, India
Author contributions: Yadav A wrote the paper; Kumar A conceptualized, corrected, and finalized the manuscript; Siddiqui MH helped in language polishing, editing, and correction in revising the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ashok Kumar, FRCS, MS, Professor, Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow 226014, Uttar Pradesh, India. doc.ashokgupta@gmail.com
Received: April 1, 2021
Peer-review started: April 1, 2021
First decision: July 6, 2021
Revised: July 15, 2021
Accepted: November 15, 2021
Article in press: November 15, 2021
Published online: December 24, 2021
Peer-review started: April 1, 2021
First decision: July 6, 2021
Revised: July 15, 2021
Accepted: November 15, 2021
Article in press: November 15, 2021
Published online: December 24, 2021
Core Tip
Core Tip: Circulating tumour cells (CTCs) in the blood have been found to be mainly associated with the stage of the disease and serve as a prognostic marker for survival in colorectal cancer. Some studies have also reported its role in the diagnosis and treatment monitoring. By focusing molecular research on rare CTCs, targeting cellular markers of CTCs, and discovering new cellular markers may improve the management of colorectal cancer and play a role in prevention of metastatic disease. Patients at high risk might benefit from additional individualized treatment which can be investigated in future clinical trials.