Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jan 24, 2021; 12(1): 13-30
Published online Jan 24, 2021. doi: 10.5306/wjco.v12.i1.13
Evolutionary model of brain tumor circulating cells: Cellular galaxy
Parvin Mehdipour, Firoozeh Javan, Morteza Faghih Jouibari, Mehdi Khaleghi, Masoud Mehrazin
Parvin Mehdipour, Firoozeh Javan, Department of Medical Genetics, Tehran University of Medical Sciences, School of Medicine, Tehran 1417613151, Tehran, Iran
Morteza Faghih Jouibari, Department of Neurosurgery, Shariati University Hospital, Tehran 1417613151, Tehran, Iran
Mehdi Khaleghi, Shariati Hospital, Tehran University of Medical Sciences, Tehran 1417613151, Tehran, Iran
Masoud Mehrazin, Tehran University of Medical Science, Tehran 1417613151, Tehran, Iran
Author contributions: Mehdipour P designed the research and protocols, analyzed the data, and wrote the paper; Javan F performed the technical protocols; Jouibari MF, Khaleghi M, and Mehrazin M provided the samples and patient information.
Supported by Tehran University of Medical Sciences, Research deputy under project, No. 32208-30-04-95.
Institutional review board statement: The study was reviewed and approved by the [IR.TUMS.MEDICINE] Institutional Review Board, No. 1395.1893.
Conflict-of-interest statement: The author and co-authors have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Parvin Mehdipour, PhD, Professor, Department of Medical Genetics, Tehran University of Medical Sciences, School of Medicine, Tehran 1417613151, Tehran, Iran. mehdipor@tums.ac.ir
Received: July 29, 2020
Peer-review started: July 29, 2020
First decision: October 18, 2020
Revised: November 5, 2020
Accepted: November 28, 2020
Article in press: November 28, 2020
Published online: January 24, 2021
Processing time: 171 Days and 16.9 Hours
Core Tip

Core Tip: The present data revealed that a classified/functional/individualized cell-based preventive and therapeutic strategy is required for the cancer management. An interaction between chemoattractant chemokine ligand 2/epidermal growth factor/vascular endothelial growth factor is an influential and key utility in the approach of cancer cells. Tracing the tumor/circulating tumor cells evolution will facilitate the estimation of functional alterations in blood stream as a model to predict the probable initiative step for metastasis, formulating the progressive status of disease and by planning for a translational/personalized management. Finally, heterogeneity and diversity may minimize the severity of disease.