Curia MC, Catalano T, Aceto GM. MUTYH: Not just polyposis. World J Clin Oncol 2020; 11(7): 428-449 [PMID: 32821650 DOI: 10.5306/wjco.v11.i7.428]
Corresponding Author of This Article
Maria Cristina Curia, PhD, DSc, Associate Professor, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti-Pescara, Chieti, Via dei Vestini 66100, Italy. mc.curia@unich.it
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jul 24, 2020; 11(7): 428-449 Published online Jul 24, 2020. doi: 10.5306/wjco.v11.i7.428
MUTYH: Not just polyposis
Maria Cristina Curia, Teresa Catalano, Gitana Maria Aceto
Maria Cristina Curia, Gitana Maria Aceto, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti-Pescara, Chieti, Via dei Vestini 66100, Italy
Teresa Catalano, Department of Clinical and Experimental Medicine, University of Messina, Messina, Via Consolare Valeria 98125, Italy
Author contributions: Curia MC, Catalano T and Aceto GM contributed equally to this paper with regard to the design of the study, literature review and analysis, writing, and approval of the final version.
Supported bythe Italian Ministry of University and Research, with funds AT-Ricerca2019Curia, FFABRUNIME2019Catalano and AT-Ricerca2019Aceto.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest regarding the publication of this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Maria Cristina Curia, PhD, DSc, Associate Professor, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti-Pescara, Chieti, Via dei Vestini 66100, Italy. mc.curia@unich.it
Received: February 28, 2020 Peer-review started: March 2, 2020 First decision: April 2, 2020 Revised: May 8, 2020 Accepted: May 27, 2020 Article in press: May 27, 2020 Published online: July 24, 2020 Processing time: 142 Days and 9 Hours
Core Tip
Core tip: This review focuses on the role of MUTYH, linked to MUTYH associated polyposis syndrome, on human neoplastic and non-neoplastic diseases, different to polyposis and colorectal cancer, considering its involvement in disorders based on oxidative stress damage. MUTYH pathogenic variants are independent predictors of poor prognosis in sporadic gastric, salivary gland secretory, pancreatic ductal, lung and cervical cancers, whereas some variants are involved in degenerative disorders, including neurological and ocular diseases. This provides novel insights for identifying the molecular basis of MUTYH pathogenesis in the light of recent advances, to better understand its potential in disease prevention and identify new therapeutic targets.
