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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2020; 11(4): 190-204
Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.190
Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.190
Nephrotoxicity in cancer treatment: An overview
Maria Luísa Cordeiro Santos, Breno Bittencourt de Brito, Filipe Antônio França da Silva, Anelise Costa dos Santos Botelho, Fabrício Freire de Melo, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029094, Bahia, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Postdoctoral Fellow, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029094, Bahia, Brazil. freiremelo@yahoo.com.br
Received: December 29, 2019
Peer-review started: December 29, 2019
First decision: January 19, 2020
Revised: January 24, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 24, 2020
Processing time: 115 Days and 6.6 Hours
Peer-review started: December 29, 2019
First decision: January 19, 2020
Revised: January 24, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 24, 2020
Processing time: 115 Days and 6.6 Hours
Core Tip
Core tip: Nephrotoxicity is an adverse event that is well described with the use of conventional cytotoxic agents and with the advent of new agents directed to specific genes/proteins in recent decades. Its nephrotoxic potential has also been observed, which limits the effectiveness of treatment and increases the morbidity and mortality of these patients. Our objective was to recognize the main chemotherapeutic drugs with nephrotoxic potential and the most common types of kidney injury to prevent or at least reduce their occurrence and severity, allowing better therapeutic indices.