Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 24, 2020; 11(11): 959-967
Published online Nov 24, 2020. doi: 10.5306/wjco.v11.i11.959
Chemotherapy rechallenge in metastatic colon cancer: A case report and literature review
Tejaswini Parlapalle Reddy, Usman Khan, Ethan Alexander Burns, Maen Abdelrahim
Tejaswini Parlapalle Reddy, College of Medicine, Texas A&M University Health Science Center, Bryan, TX 77807, United States
Usman Khan, Ethan Alexander Burns, Maen Abdelrahim, Department of Medical Oncology, Houston Methodist Hospital Cancer Center, Houston, TX 77030, United States
Maen Abdelrahim, Section of GI Oncology, Department of Medical Oncology, Houston Methodist Cancer Center. Cockrell Center of Advanced Therapeutics Phase I Program, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX 77030, United States
Author contributions: Reddy TP reviewed the literature; Reddy TP, Burns EA, Khan U, Abdelrahim M contributed to the design of the manuscript and manuscript drafting, and revision of the manuscript for intellectual content; Khan U imaged analysis and interpretation; Abdelrahim M was the patient’s oncologist and was responsible for the critical revision of the manuscript for intellectual content; and all authors issued final approval for the version to be submitted.
Informed consent statement: Verbal consent was obtained from the patient for publication of this report and any accompanying radiographic images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maen Abdelrahim, BPharm, MD, PhD, Associate Professor, Section of GI Oncology, Department of Medical Oncology, Houston Methodist Cancer Center. Cockrell Center of Advanced Therapeutics Phase I Program, Houston Methodist Research Institute and Weill Cornell Medical College, 6445 Main ST Fl 24, Houston, TX 77030, United States. mabdelrahim@houstonmethodist.org
Received: August 5, 2020
Peer-review started: August 5, 2020
First decision: September 17, 2020
Revised: October 1, 2020
Accepted: October 19, 2020
Article in press: October 19, 2020
Published online: November 24, 2020
Processing time: 104 Days and 20 Hours
Core Tip

Core Tip: Despite advances in therapeutic strategies, colorectal cancer (CRC) remains a deadly disease. There are limited options for patients with chemo-refractory mCRC. We present a case of a patient with heavily treated metastatic colorectal cancer (mCRC) that was responsive to oxaliplatin-based rechallenge therapy. Oxaliplatin rechallenge therapy provided this patient with a ten-month survival benefit, marked improvement in his clinical condition, performance status, and quality of life. This case highlights the importance of considering rechallenge therapy in patients with chemo-refractory mCRC. Monitoring for oxaliplatin-associated peripheral sensory neuropathy should be considered for patients who are candidates for oxaliplatin rechallenge therapy.