Feeney L, Harley IJ, McCluggage WG, Mullan PB, Beirne JP. Liquid biopsy in ovarian cancer: Catching the silent killer before it strikes. World J Clin Oncol 2020; 11(11): 868-889 [PMID: 33312883 DOI: 10.5306/wjco.v11.i11.868]
Corresponding Author of This Article
James P Beirne, MBChB, PhD, Doctor, Trinity St James Cancer Institute, St. James’ Hospital, James’ Street, Dublin 8, Ireland. jbeirne@stjames.ie
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Nov 24, 2020; 11(11): 868-889 Published online Nov 24, 2020. doi: 10.5306/wjco.v11.i11.868
Liquid biopsy in ovarian cancer: Catching the silent killer before it strikes
Laura Feeney, Ian JG Harley, W Glenn McCluggage, Paul B Mullan, James P Beirne
Laura Feeney, Paul B Mullan, Patrick G Johnston Centre for Cancer Research, Queens University, Belfast BT9 7AE, United Kingdom
Ian JG Harley, Northern Ireland Gynaecological Cancer Centre, Belfast Health and Social Care Trust, Belfast BT9 7AB, United Kingdom
W Glenn McCluggage, Department of Pathology, Belfast Health and Social Care Trust, Belfast BT12 6BL, United Kingdom
James P Beirne, Trinity St James Cancer Institute, St. James’ Hospital, Dublin 8, Ireland
Author contributions: Beirne JP and Feeney L wrote the manuscript; Mullan PB provided guidance on, and reviewed the content of, the scientific aspects of liquid biopsy; McCluggage WG provided guidance on, and reviewed the content of, the pathological aspects of the manuscript; Harley IJ provided guidance on, and reviewed the content of, the clinical aspects of the manuscript; and all authors reviewed and approved the article prior to submission.
Conflict-of-interest statement: The authors have no conflicts to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: James P Beirne, MBChB, PhD, Doctor, Trinity St James Cancer Institute, St. James’ Hospital, James’ Street, Dublin 8, Ireland. jbeirne@stjames.ie
Received: March 29, 2020 Peer-review started: March 29, 2020 First decision: June 20, 2020 Revised: July 29, 2020 Accepted: November 4, 2020 Article in press: November 4, 2020 Published online: November 24, 2020 Processing time: 233 Days and 14.6 Hours
Core Tip
Core Tip: Epithelial ovarian cancer (EOC), particularly high-grade serous carcinoma, is a gynaecological malignancy with a poor survival rate. Currently there is no effective disease-specific biomarker, which could improve detection rates and treatment algorithms, for any of the EOC types - this is an area of unmet clinical need. Circulating tumour DNA (ctDNA) analysis has emerged as a potential blood-based “liquid biopsy” for early detection, diagnosis, staging and prognosis, monitoring response to treatment, monitoring minimal residual disease and relapse and identifying acquired drug resistance mechanisms. However, there are several obstacles to the development of cfDNA-based biomarkers which are discussed further in this in-depth review.
