Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2019; 10(2): 86-97
Published online Feb 24, 2019. doi: 10.5306/wjco.v10.i2.86
Impact of conditioning regimen on peripheral blood hematopoietic cell transplant
Michael Burns, Anurag K Singh, Carrie C Hoefer, Yali Zhang, Paul K Wallace, George L Chen, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Christopher Choi, Maureen Ross, Philip L McCarthy, Theresa Hahn
Michael Burns, Carrie C Hoefer, Yali Zhang, George L Chen, Maureen Ross, Philip L McCarthy, Theresa Hahn, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States
Anurag K Singh, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States
Paul K Wallace, Department of Flow Cytometry, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States
Christopher Choi, Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States
Author contributions: Burns M designed and performed the research and wrote the paper; Singh AK and Hoefer CC designed the research and supervised the report; Zhang Y and Wallace PK analyzed data; Platek A, Choi C, and Winslow TB performed the research; Iovoli AJ analyzed data and edited the report; Chen GL and Ross M provided clinical advice; McCarthy PL and Hahn T supervised the report.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Roswell Park Comprehensive Cancer Center.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Anurag K Singh, MD, Professor, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States. anurag.singh@roswellpark.org
Telephone: +1-716-8451180 Fax: +1-716-8457616
Received: July 30, 2018
Peer-review started: July 30, 2018
First decision: September 11, 2018
Revised: September 14, 2018
Accepted: December 4, 2018
Article in press: December 5, 2018
Published online: February 24, 2019
Processing time: 207 Days and 10.7 Hours
Core Tip

Core tip: This study investigated infused hematopoietic cell doses and their interaction with conditioning regimen intensity on outcomes after peripheral blood hematopoietic cell transplant. Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic peripheral blood hematopoietic cell transplant. Neutrophil engraftment was significantly faster after reduced intensity total body irradiation and > 4 × 106 CD34+ cells/kg infused. Overall and progression-free survival was significantly better in patients with a reduced intensity conditioning and total body irradiation regimen and total nucleated cell dose > 8 × 108/kg.