Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Treatment of patients with multiple brain metastases by isolated radiosurgery: Toxicity and survival
André Vinícius de Camargo, Marcos Duarte de Mattos, Murilo Kenji Kawasaki, Danilo Nascimento Salviano Gomes, Allisson Bruno Barcelos Borges, Vinicius de Lima Vazquez, Raphael L C Araujo
André Vinícius de Camargo, Marcos Duarte de Mattos, Murilo Kenji Kawasaki, Danilo Nascimento Salviano Gomes, Department of Radiotherapy, Barretos Cancer Hospital, São Paulo, Barretos 14784-400, Brazil
Allisson Bruno Barcelos Borges, Department of Radiation Therapy, Hospital DF Star Rede D´Or, Brasília 70390-140, Brazil
Vinicius de Lima Vazquez, Department of Surgery, Barretos Cancer Hospital, São Paulo, Barretos 14784-400, Brazil
Raphael L C Araujo, Department of Surgery, Universidade Federal de São Paulo, São Paulo 04024-002, Brazil
Raphael L C Araujo, IEP, Barretos Cancer Hospital, São Paulo, Barretos 14784-400, Brazil
Author contributions: de Camargo AV, Borges ABB, Vazquez VL, and Araujo RLC contributed to conceptualization; de Camargo AV, de Mattos MD, Kawasaki MK, Gomes DNS, and Borges ABB contributed to data collection; de Camargo AV and Araujo RLC contributed to data analysis; all authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Barretos Cancer Hospital.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Raphael L C Araujo, MD, PhD, Adjunct Professor, Surgical Oncologist, Department of Surgery, Universidade Federal de São Paulo, No. 715 Napoleão de Barros Street, São Paulo 04024-002, Brazil. raphaellcaraujo@gmail.com
Received: June 27, 2023
Peer-review started: June 27, 2023
First decision: August 10, 2023
Revised: September 1, 2023
Accepted: September 22, 2023
Article in press: September 22, 2023
Published online: October 24, 2023
ARTICLE HIGHLIGHTS
Research background
Radiosurgery for multiple brain metastases has been more reported recently without using whole-brain radiotherapy, but mainly for oligometastatic scenarios (up to 3-4 lesions). Nevertheless, the sparsity of the data still claims more information about toxicity and survival and their association with both dosimetric and geometric aspects of this treatment, especially for the presence of more lesions or in patients with previous irradiation.
Research motivation
To evaluate the toxicity of treatment offered for patients with four or more lesions.
Research objectives
To assess associations of toxicity and survival outcome of stereotactic radiosurgery (SRS) among patients with four or more brain lesions with or without previous brain irradiation.
Research methods
Retrospective cohort.
Research results
Neither difference in toxicity nor survival was detected when comparing patients who underwent SRS for four or more brain lesions with or without previous brain irradiation.
Research conclusions
This retrospective study did not detect differences in toxicity for this population with or without previous irradiation, suggesting that the use of SRS for four or more brain lesions with or without previous brain irradiation is safe.
Research perspectives
This study claims for more data in larger studies in a prospective manner to better address this question.
