Retrospective Cohort Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 24, 2022; 13(11): 907-917
Published online Nov 24, 2022. doi: 10.5306/wjco.v13.i11.907
Epidemiologic risk factors for patients admitted with chronic pancreatitis and pancreatic ductal adenocarcinoma in the United States
Daniel Lew, Fatima Kamal, Khiem Phan, Karamvir Randhawa, Sam Cornwell, Ayrton I Bangolo, Simcha Weissman, Stephen J Pandol
Daniel Lew, Stephen J Pandol, Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States
Fatima Kamal, Khiem Phan, Karamvir Randhawa, Sam Cornwell, Ayrton I Bangolo, Simcha Weissman, Department of Internal Medicine, Hackensack Meridian Health/Palisades Medical Center, North Bergen, NJ 07047, United States
Author contributions: Lew D, Kamal F, Phan K, Randhawa K, Cornwell S, and Weissman S assisted with data acquisition, analyses, and manuscript preparation; Lew D drafted and critically revised the manuscript; Lew D, Weissman S, Bangolo AI, and Pandol SJ provided input regarding methodology; Pandol SJ critically revised the manuscript and provided direct supervision and guidance; Weissman S is the article guarantor; All authors agree to the final version of this manuscript.
Institutional review board statement: This retrospective cohort study utilized the 2016 and 2017 National Inpatient Sample (NIS) databases. The NIS is a database of inpatient stays derived from billing data based upon discharge abstracts. As such, it contains de-identified clinical and nonclinical elements at both the patient and hospital level. Making the need for an Institutional review board approval dispensable.
Informed consent statement: The National Inpatient Database was a public-use dataset, of which the informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: This retrospective cohort study utilized the 2016 and 2017 National Inpatient Sample (NIS) databases. The NIS is a database of inpatient stays derived from billing data based upon discharge abstracts. As such, it contains de-identified clinical and nonclinical elements at both the patient and hospital level. The dataset is publicly available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ayrton I Bangolo, MBBS, MD, Doctor, Department of Internal Medicine, Hackensack Meridian Health/Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, United States. ayrtonbangolo@yahoo.com
Received: July 28, 2022
Peer-review started: July 28, 2022
First decision: September 5, 2022
Revised: September 8, 2022
Accepted: November 6, 2022
Article in press: November 6, 2022
Published online: November 24, 2022
ARTICLE HIGHLIGHTS
Research background

Chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) rates are rising. Pancreatitis admissions costed 133 million dollars, and accounted for the 3rd leading cause of hospital admissions. There is lack of data identifying those at highest risk for admissions with CP and PDAC.

Research motivation

The main motivation of this study was to establish racial risk factors and their associations with PDAC.

Research objectives

This study had the objective to examine the demographic, ethno-racial, socioeconomic, and hospital factors associated with hospitalizations for CP and its association with PDAC.

Research methods

This retrospective study used the 2016 and 2017 National Inpatient Sample databases. ICD-10 codes compatible with CP and PDAC were used in the study. The ethnic, socioeconomic, and racial backgrounds of patients with CP and PDAC were analyzed.

Research results

Hospital admissions for CP was 29 per 100000, and 2890 (0.78%) had PDAC. Blacks [adjusted odds ratio (aOR) 1.13], men (aOR 1.35), age 40 to 59 (aOR 2.60), and being overweight (aOR 1.34) were significantly associated with CP (all with P < 0.01). In patients with CP, Whites (aOR 1.23), higher income, older age (aOR 1.05), and being overweight (aOR 2.40) were all significantly associated with PDAC (all with P < 0.01). Men (aOR 1.81) and Asians (aOR 15.19) had significantly increased mortality (P < 0.05). Hispanics had significantly increased hospital length of stay (aOR 5.24) (P < 0.05).

Research conclusions

There is an increased trend in hospitalization rates for CP, predominantly among black men between 40-59 years old who were overweight. Wealthy white men above the age of 40 had a higher PDAC diagnosis.

Research perspectives

Black men between 40-59 years old and overweight are at significantly increased risk for admission with CP. White men with higher income were found to have significantly increased risk for admissions with CP and PDAC. Asians/Pacific Islanders had the highest risk for mortality from CP and PDAC.