Bolzacchini E, Nigro O, Inversini D, Giordano M, Maconi G. Intestinal metastasis from breast cancer: Presentation, treatment and survival from a systematic literature review. World J Clin Oncol 2021; 12(5): 382-392 [PMID: 34131569 DOI: 10.5306/wjco.v12.i5.382]
Corresponding Author of This Article
Elena Bolzacchini, MD, Doctor, Department of Oncology, Ospedale Sant' Anna, ASST Lariana, Via Ravona 20, San Fermo della Battaglia, Como 22100, Italy. elena.bolzacchini@hotmail.it
Research Domain of This Article
Oncology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. May 24, 2021; 12(5): 382-392 Published online May 24, 2021. doi: 10.5306/wjco.v12.i5.382
Intestinal metastasis from breast cancer: Presentation, treatment and survival from a systematic literature review
Elena Bolzacchini, Olga Nigro, Davide Inversini, Monica Giordano, Giovanni Maconi
Elena Bolzacchini, Department of Oncology, Ospedale Sant' Anna, ASST Lariana, Como 22100, Italy, Department of Medicine and Surgery, University of Insubria, Varese 21100, Italy
Olga Nigro, Department of Oncology, Ospedale di Circolo ASST-Sette Laghi, Varese 21100, Italy
Davide Inversini, Department of General Surgery, Ospedale Sant' Antonio Abate, ASST Lariana, Cantu' 22100, Italy.
Monica Giordano, Department of Oncology, Ospedale Sant' Anna, ASST Lariana, Como 22100, Italy
Giovanni Maconi, Department of Biomedical and Clinical Sciences, Gastroenterology Unit, "Luigi Sacco" University Hospital, Milano 20157, Italy
Author contributions: All authors contributed to the study conception and design; material preparation, data collection and analysis were performed by Bolzacchini E, Nigro O, Inversini D and Maconi G; the first draft of the manuscript was written by Bolzacchini E and Maconi G; Giordano M revised it carefully; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Elena Bolzacchini, MD, Doctor, Department of Oncology, Ospedale Sant' Anna, ASST Lariana, Via Ravona 20, San Fermo della Battaglia, Como 22100, Italy. elena.bolzacchini@hotmail.it
Received: January 5, 2021 Peer-review started: January 5, 2021 First decision: January 18, 2021 Revised: January 23, 2021 Accepted: April 13, 2021 Article in press: April 13, 2021 Published online: May 24, 2021
ARTICLE HIGHLIGHTS
Research background
Intestinal metastasis from breast cancer (BC) is considered rare.
Research motivation
We conducted a review of the literature regarding intestinal metastasis from BC.
Research objectives
We conducted a review of the literature regarding presentation, diagnosis, treatment and survival of patients with intestinal metastasis from BC.
Research methods
We identified all articles that described patients with intestinal metastasis from BC using MEDLINE and EMBASE electronic databases until 2020.
Research results
We found 96 cases of intestinal metastasis of BC. Metastasization involved large bowel in 51% of the cases, small bowel in 49% of the cases, and anum in less than 1%. Median age of patients was 61-year-old. The most frequent histology was infiltrating lobular carcinoma followed by infiltrating ductal carcinoma. In more than half of patients the diagnosis was made after the diagnosis of BC and in many cases in emergency setting, for bowel obstruction, bleeding or perforation. Diagnosis was achieved through endoscopy, radiological examination or both. In most of the cases patients underwent surgery with or without systemic therapies.
Research conclusions
Although intestinal metastases of BC are considered a rare condition, several cases are reported from the available literature.
Research perspectives
Our paper comprehends summarizes epidemiology, symptoms, diagnostic work-up, therapy and survival of this condition. On this account it gives an estimate of the problem and could lead to and represent the basis for the creation of a multicentre prospective study or a registry.
