Published online Feb 10, 2018. doi: 10.5306/wjco.v9.i1.13
Peer-review started: September 24, 2017
First decision: November 7, 2017
Revised: November 7, 2017
Accepted: November 25, 2017
Article in press: November 25, 2017
Published online: February 10, 2018
Processing time: 137 Days and 15.6 Hours
To determine the clinical characteristics of patients undergoing palliative surgery for Krukenberg tumors, including disease presentation, outcomes, and prognostic factors.
This was a retrospective clinical study of all patients who underwent palliative surgery for Krukenberg tumors between January 2004 and December 2015. Patient information was obtained from inpatient and outpatient case notes as well as the hospital electronic records. Patients who underwent potentially curative resection, and patients with Krukenberg tumors who did not undergo surgery were also excluded from the study. Palliative surgery was defined as those performed for either alleviation of symptoms or for asymptomatic patients for whom surgical removal of the tumors were deemed necessary following a multidisciplinary consensus. Tumors were diagnosed pre-operatively by computed tomography scans and all had histologic confirmation of the surgical specimens.
Over the study duration, 38 female patients underwent palliative surgery for Krukenberg tumors at our institution. Mean age was 54.2 ± 11.7 years. The colon was the most frequent primary source of metastases (n = 21) followed by the stomach (n = 4). Prophylactic palliative surgery was performed for eight (21.1%) asymptomatic patients. Median post-operative length of stay was 8 d (IQR 6-12 d). Five patients (13.2%) experienced post-operative complications, although high grade morbidity was only seen in one patient (2.6%). Median overall survival from surgery was 17 mo (95%CI: 12.1-21.9) at a median follow-up duration of 12 mo (IQR 8-17 mo). The median survival was shorter for patients who underwent emergency surgery, younger patients, those with a colorectal primary, larger tumors, or synchronous peritoneal or hepatic metastases.
Palliative surgery for Krukenberg tumors can be performed safely with acceptable complication rates. Bilateral oophorectomy should be performed to prevent the risk of symptomatic contralateral tumors.
Core tip: Krukenberg tumors represent metastases to the ovary and convey a poor prognosis. By reporting our 12-year experience with palliative surgery for Krukenberg tumors and discussing the existing literature, we hope to shed light and establish best practices on the approach to management of the disease. Palliative surgery for patients with Krukenberg tumors can be performed safely in an experienced unit with acceptable complication rates. Where possible, bilateral oophorectomy should be performed to obviate the risk of the contralateral ovary developing symptomatic tumors. Appropriate selection by a multidisciplinary consensus is essential for asymptomatic patients who may benefit from prophylactic surgery.