Rao A, Ingle SB, Rajurkar P, Goyal V, Dokrimare N. Malignant peripheral nerve sheath tumor of proximal third tibia. World J Clin Oncol 2015; 6(5): 179-183 [PMID: 26468455 DOI: 10.5306/wjco.v6.i5.179]
Corresponding Author of This Article
Sachin B Ingle, Professor, Department of Pathology, Secretary Research and Development and Institutional Review Board, Maharashtra Institute of Medical Sciences and Research Medical College, Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr.sachiningle@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Arunkumar Rao, Pawan Rajurkar, Vishav Goyal, Nikhil Dokrimare, Department of Orthopedics, Maharashtra Institute of Medical Sciences and Research, Medical College, Latur 413512, Maharashtra, India
Sachin B Ingle, Department of Pathology, Secretary Research and Development and Institutional Review Board, Maharashtra Institute of Medical Sciences and Research, Medical College, Latur 413531, Maharashtra, India
Author contributions: Rao A and Rajurkar P designed the study; Goyal V and Dokrimare N prepared the first draft of the manuscript; Ingle SB carried outthe pathological diagnosis, and critically revised the intellectual content of the manuscript and gave itfinal approval.
Institutional review board statement: Approved by Institutional Review board of Maharashtra Institute of Medical Sciences and Research,Medical College, Latur.
Informed consent statement: As we are not disclosing theidentity of the patient, it wasnot needed.
Conflict-of-interest statement: All authors clear that they have no any conflicts of interests to be declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sachin B Ingle, Professor, Department of Pathology, Secretary Research and Development and Institutional Review Board, Maharashtra Institute of Medical Sciences and Research Medical College, Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr.sachiningle@gmail.com
Telephone: +91-2382-227424 Fax: +91-2382-228939
Received: February 7, 2015 Peer-review started: February 8, 2015 First decision: May 14, 2015 Revised: June 8, 2015 Accepted: June 18, 2015 Article in press: June 19, 2015 Published online: October 10, 2015 Processing time: 248 Days and 0.5 Hours
Abstract
A 16-year-old man had aswelling over the anterior aspect of the proximal third of the tibia for 1 year, which was peanut size initially and progressively increased to its present size of 10 cm × 8 cm. He underwent fine needle aspiration cytology (FNAC) twice during this period and reported aspindle cell sarcoma. Malignant peripheral nerve sheath tumor (MPNST) is a malignancy of the connective tissue surrounding the nerves. Previously, MPNST was also known as neurofibrosarcoma, malignant schwannoma, andneurogenic sarcoma. We are reporting this case for its rarity and peculiar mode of presentation. FNAC/core biopsy can be used as an effective tool to achievethe correct pathological diagnosis.
Core tip: In cases of malignant peripheral nerve sheath tumor of the tibia, fine needle aspiration cytology/core biopsy can be used as an effective tool to achieve the correct pathological diagnosis. In such cases, en bloc resection is the treatment of choice. Adjuvant radiotherapy/chemotherapy plays a vital role in achieving a good outcome.
