Nampoolsuksan C, Parakonthun T. Enhanced recovery after surgery protocols in gastrectomy with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer. World J Clin Oncol 2025; 16(8): 107533 [DOI: 10.5306/wjco.v16.i8.107533]
Corresponding Author of This Article
Thammawat Parakonthun, MD, Associate Professor, Siriraj Upper Gastrointestinal Cancer Center, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Road, Bangkoknoi, Bangkok 10700, Thailand. thammawat.paa@mahidol.ac.th
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Aug 24, 2025; 16(8): 107533 Published online Aug 24, 2025. doi: 10.5306/wjco.v16.i8.107533
Enhanced recovery after surgery protocols in gastrectomy with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer
Chawisa Nampoolsuksan, Thammawat Parakonthun
Chawisa Nampoolsuksan, Thammawat Parakonthun, Siriraj Upper Gastrointestinal Cancer Center, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Author contributions: Nampoolsuksan C was responsible for conceptualization, data curation, formal analysis, investigation, methodology, resources, validation, writing original draft preparation, writing review and editing; Parakonthun T was responsible for conceptualization, data curation, investigation, resources, software, supervision, writing original draft preparation, writing review and editing; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Thammawat Parakonthun, MD, Associate Professor, Siriraj Upper Gastrointestinal Cancer Center, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Road, Bangkoknoi, Bangkok 10700, Thailand. thammawat.paa@mahidol.ac.th
Received: March 26, 2025 Revised: May 7, 2025 Accepted: July 10, 2025 Published online: August 24, 2025 Processing time: 147 Days and 22.7 Hours
Abstract
Gastric cancer with peritoneal carcinomatosis (PC) remains a formidable challenge in oncological care, especially regarding surgical intervention. Integrating enhanced recovery after surgery (ERAS) protocols into gastrectomy with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy has emerged as a promising approach. This minireview explores the influence of ERAS on surgical and oncological outcomes in this multifaceted procedure. Recent evidence suggests that ERAS, comprising multimodal strategies, improves postoperative recovery, reduces complications, and enhances quality of life. It may also contribute to better survival outcomes by minimizing perioperative morbidity and thereby facilitating the timely initiation of adjuvant therapy. Mechanistically, ERAS promotes early mobilization, attenuates postoperative immunosuppression, and supports timely adjuvant therapies, which are crucial in managing carcinomatosis. This minireview underscores the importance of multidisciplinary collaboration and individualized patient care to maximize ERAS benefits. Large-scale, prospective investigations are warranted to validate these findings and refine ERAS protocols for this specialized patient cohort. Further research will facilitate ongoing advancements in oncological surgery and perioperative care, ultimately improving outcomes for patients with gastric cancer and PC.
Core Tip: Implementing enhanced recovery after surgery (ERAS) protocols in gastrectomy with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal carcinomatosis can enhance postoperative recovery and potentially improve survival. A multidisciplinary approach that reduces surgical stress, optimizes perioperative care, and ensures timely adjuvant therapy remains essential. Further research is needed to refine ERAS strategies for this complex patient population.
