Shi GJ, Wang C, Zhang P, Lu YY, Zhou HP, Ma RQ, An LB. Pseudomyxoma peritonei originating from small intestine: A case report and review of literature. World J Clin Oncol 2025; 16(4): 103564 [DOI: 10.5306/wjco.v16.i4.103564]
Corresponding Author of This Article
Lu-Biao An, Department of Myxoma, Aerospace Center Hospital, No. 15 Yuquan Road, Haidian District, Beijing 100049, China. 280604060@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Apr 24, 2025; 16(4): 103564 Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.103564
Pseudomyxoma peritonei originating from small intestine: A case report and review of literature
Guan-Jun Shi, Chong Wang, Pu Zhang, Yi-Yan Lu, Hai-Peng Zhou, Rui-Qing Ma, Lu-Biao An
Guan-Jun Shi, Chong Wang, Pu Zhang, Hai-Peng Zhou, Rui-Qing Ma, Lu-Biao An, Department of Myxoma, Aerospace Center Hospital, Beijing 100049, China
Yi-Yan Lu, Department of Pathology, Aerospace Center Hospital, Beijing 100049, China
Co-first authors: Guan-Jun Shi and Chong Wang.
Co-corresponding authors: Rui-Qing Ma and Lu-Biao An.
Author contributions: Shi GJ and Wang C conceptualized the research and drafted the manuscript; both authors contribute equally to this study as co-first authors; Ma RQ and An LB contribute equally to this study as co-corresponding authors; Zhang P and Zhou HP collected data; Lu YY interpreted the pathological findings; Ma RQ and An LB reviewed and revised the manuscript; all the authors have read and approved the final version of the manuscript to be published.
Supported by 2024 Aerospace Center Hospital Scientific Research Fund, No. YN202410.
Informed consent statement: The protocol for this study was approved by the Ethics Committee of the Aerospace Center Hospital, Beijing, China (No. 2024-081). The written informed consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lu-Biao An, Department of Myxoma, Aerospace Center Hospital, No. 15 Yuquan Road, Haidian District, Beijing 100049, China. 280604060@qq.com
Received: November 25, 2024 Revised: December 24, 2024 Accepted: January 18, 2025 Published online: April 24, 2025 Processing time: 123 Days and 8.5 Hours
Abstract
BACKGROUND
Pseudomyxoma peritonei (PMP) is a distinct form of peritoneal malignancy characterized by diffuse intra-abdominal gelatinous ascites, with an estimated incidence of 1-3 per 1000000. PMP is predominantly secondary to appendiceal mucinous neoplasms, with rarer origins including the ovaries, colon, and urachus. However, PMP originating from small intestine is extremely rare.
CASE SUMMARY
A 60-year-old male patient presented with anorexia and abdominal distension. Computed tomography revealed the presence of abdominopelvic effusions and multiple intra-abdominal space-occupying lesions. Ultrasound-guided aspiration indicated that the aspirated tissue was mucinous. Exploratory laparoscopy and tissue biopsy identified diffuse tumor nodules in peritoneum, omentum, pelvic region, intestinal walls, and mesentery. Histopathological analysis of the resected tumors confirmed the presence of mucinous adenocarcinoma, but the primary lesion was difficult to determine. The patient was referred to our center for further treatment and underwent cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) under general anesthesia. The intraoperative peritoneal cancer index was 30. The surgery lasted 8 hours, with a blood loss of about 600 mL. A complete cytoreduction (CCR0) was achieved. No serious complications occurred after surgery, and the patient’s condition was good during the telephone follow-up. Postoperative pathology confirmed the diagnosis of small intestinal mucinous adenocarcinoma at proximal jejunum, which was complicated by high-grade PMP.
CONCLUSION
PMP originating from small intestine is an exceptionally rare entity that exhibits non-specific clinical features. The preferred treatment is CRS + HIPEC.
Core Tip: Pseudomyxoma peritonei (PMP) is a distinct type of peritoneal malignancy that predominantly originates from appendiceal mucinous neoplasms, and PMP originating from small intestine is extremely rare. Here we report a case of PMP originating from the jejunum in an attempt to enhance our understanding of this disease.
