Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2025; 16(4): 103343
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.103343
Overview of serrated polyposis syndrome from pathophysiology, diagnosis, and management
Zong-Yang Li, Tong Li, Hong-Qiao Cai
Zong-Yang Li, Tong Li, Hong-Qiao Cai, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Cai HQ designed the overall concept and outline of the manuscript; Li ZY contributed to the discussion and design of the manuscript; Li T and Cai HQ contributed to the writing, and editing the manuscript, illustrations, and review of literature.
Conflict-of-interest statement: The authors have claimed no conflicts.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Qiao Cai, MD, PhD, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. hongqiaocai@jlu.edu.cn
Received: November 18, 2024
Revised: January 24, 2025
Accepted: February 14, 2025
Published online: April 24, 2025
Processing time: 129 Days and 10.3 Hours
Abstract

This editorial discusses Thompson et al's original article, which is published in the most recent edition of the World Journal of Clinical Oncology and sheds critical light on the intertwined issues of health anxiety and work loss in individuals diagnosed with serrated polyposis syndrome (SPS). SPS is rare, characterized by the development of multiple serrated colorectal polyps. This editorial provides an overview of SPS, including its pathophysiology, clinical presentation, diagnostic criteria, management strategies, and the psychosocial impact. SPS is linked to molecular alterations, which drive carcinogenesis. Colonoscopy and histological analysis are used for diagnosis. Genetic testing is also considered where there is a family history. Quality of life can be greatly impacted by the psychosocial effects of SPS, especially health anxiety. Further understanding of the molecular mechanisms and creating individualized surveillance are required.

Keywords: Serrated polyposis syndrome; Pathophysiology; Diagnosis; Treatment; Psychosocial impact

Core Tip: Serrated polyposis syndrome (SPS) is a rare and clinically significant condition, marked by the presence of multiple serrated colorectal polyps, significantly increasing the risk of colorectal cancer (CRC). By a comprehensive overview of its pathophysiology, clinical manifestations, diagnostic criteria, management strategies, and the psychosocial impact on patients, a more individualized surveillance approach to minimize the risk of CRC associated with SPS should be developed.