Wang T, Cheng Y, Hu F, Wang Q. Residual gastric cancer with a mixed small cell neuroendocrine and keratinizing squamous cell carcinoma: A case report. World J Clin Oncol 2025; 16(3): 102301 [DOI: 10.5306/wjco.v16.i3.102301]
Corresponding Author of This Article
Qiang Wang, MD, Assistant Professor, Department of Gastroenterology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Nanchang 330000, Jiangxi Province, China. 15083822890@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Mar 24, 2025; 16(3): 102301 Published online Mar 24, 2025. doi: 10.5306/wjco.v16.i3.102301
Residual gastric cancer with a mixed small cell neuroendocrine and keratinizing squamous cell carcinoma: A case report
Tian Wang, Yang Cheng, Fan Hu, Qiang Wang
Tian Wang, Qiang Wang, Department of Gastroenterology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, Jiangxi Province, China
Yang Cheng, Fan Hu, Department of Pathology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, Jiangxi Province, China
Author contributions: Wang T and Wang Q performed sample collecting and manuscript writing; Cheng Y and Hu F performed pathology slide reading and performing hematoxylin and eosin and immunohistochemistry; and all authors thoroughly reviewed and endorsed the final manuscript.
Informed consent statement: Informed consent was obtained from patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiang Wang, MD, Assistant Professor, Department of Gastroenterology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Nanchang 330000, Jiangxi Province, China. 15083822890@163.com
Received: October 14, 2024 Revised: November 19, 2024 Accepted: December 9, 2024 Published online: March 24, 2025 Processing time: 99 Days and 2.3 Hours
Abstract
BACKGROUND
Despite advancements in early detection and treatment, the prognosis and histological types for residual gastric cancer (GC) remains poor.
CASE SUMMARY
This case report presents a rare occurrence of residual GC featuring a combination of small cell neuroendocrine carcinoma (SCNEC) and squamous cell carcinoma (SCC) in a 60-year-old male patient. The patient, with a history of Billroth II gastrectomy for duodenal ulcer bleeding, presented with gastrointestinal bleeding. Preoperative computed tomography and positron emission tomography-computed tomography indicated adenocarcinoma with tumor and abdominal lymph node metastasis. The patient underwent laparoscopic total gastrectomy and lymph node dissection for residual GC. Histological examination of the resected tumor confirmed the presence of both SCNEC and SCC. Postoperatively, the patient underwent adjuvant chemotherapy four times. Two years later, the patient was found to occur esophageal cancer and was performed a small bowel stoma and radical esophagectomy.
CONCLUSION
In this case report, we detail a rare instance of residual GC with mixed SCNEC and SCC, emphasizing the complexity of diagnosis and treatment, and the need for ongoing research.
Core Tip: This case report presents a unique instance of residual gastric cancer with a combination of small cell neuroendocrine carcinoma and squamous cell carcinoma, highlighting the emergence of such rare histological types post-gastrectomy underscores the need for vigilant surveillance and further research into their management. The complexity of diagnosing and treating this mixed histology gastric cancer is further emphasized by the current trends in gastric cancer management. The pursuit of integrated, resource-sensitive approaches to surveillance and treatment is crucial for enhancing outcomes in this patient population.
