Wang SY, Wang JH, Chen RK, Yuan Z, Cui H, Wei B, Cui JX. Mapping the landscape of gastric signet ring cell carcinoma: Overcoming hurdles and charting new paths for advancement. World J Clin Oncol 2025; 16(2): 98983 [DOI: 10.5306/wjco.v16.i2.98983]
Corresponding Author of This Article
Bo Wei, MD, Chief Doctor, Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. weibo@301hospital.com.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Scientometrics
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Feb 24, 2025; 16(2): 98983 Published online Feb 24, 2025. doi: 10.5306/wjco.v16.i2.98983
Mapping the landscape of gastric signet ring cell carcinoma: Overcoming hurdles and charting new paths for advancement
Shu-Yuan Wang, Jing-Hang Wang, Run-Kai Chen, Zhen Yuan, Hao Cui, Bo Wei, Jian-Xin Cui
Shu-Yuan Wang, Jing-Hang Wang, Zhen Yuan, Hao Cui, School of Medicine, Nankai University, Tianjin 300071, China
Jing-Hang Wang, Run-Kai Chen, Zhen Yuan, Hao Cui, Bo Wei, Jian-Xin Cui, Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Co-first authors: Shu-Yuan Wang and Jing-Hang Wang.
Co-corresponding authors: Bo Wei and Jian-Xin Cui.
Author contributions: Wang SY and Wang JH contribute equally to this study as co-first authors; Cui JX and Wei B contribute equally to this study as co-corresponding authors; Wang SY contributed to design of the study, data analysis and design; Wang JH contributed to data collection, figure revision and draft manuscript; Chen RK, Cui H and Yuan Z contributed to make significant revisions to the thesis; Cui JX and Wei B contributed to fund and approval of the final version of the paper.
Supported by National Natural Science Foundation of China, No. 82073192, and No. 82273231; and Beijing Science and Technology Program, No. Z221100007422125.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo Wei, MD, Chief Doctor, Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. weibo@301hospital.com.cn
Received: July 10, 2024 Revised: September 26, 2024 Accepted: November 13, 2024 Published online: February 24, 2025 Processing time: 153 Days and 20.1 Hours
Abstract
BACKGROUND
In recent years, the global prevalence of gastric cancer (GC) has witnessed a progressive decrease, accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma (GSRCC). As precision medicine concepts progress, GSRCC, a distinct sub-type of GC, has drawn considerable attention from researchers. However, there still persist some controversies regarding the associated research findings.
AIM
To summarize the current obstacles and potential future directions for research on GSRCC.
METHODS
To begin with, all literature related to GSRCC published from January 1, 2004 to December 31, 2023 was subjected to bibliometric analysis in this article. Additionally, this paper analyzed the research data using CiteSpace, GraphPad Prism v8.0.2, and VOSviewer, which was obtained from the Web of Science Core Collection database. The analysis results were visually represented.
RESULTS
This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC, including cited references, authors, journals, countries, institutions, and keywords. The popular keywords and clusters contain "prognosis", "survival", "expression", "histology", and "chemotherapy".
CONCLUSION
The prognosis, precise definition and classification, as well as chemoresistance of GSRCC, continue to be crucial areas of ongoing research, whose directions are closely tied to advancements in molecular biology research on GSRCC.
Core Tip: In this paper, the bibliometric analysis method was employed to analyze articles on the study of gastric signet ring cell carcinoma (GSRCC), and the analysis results were presented visually. The prognosis, precise definition and classification, as well as chemoresistance of GSRCC, keep up to be focal points of current research. Advancements in molecular biology research on GSRCC are indispensable for future progress in this area.
