Abutaha S, Alzibdeh A, Mohamad I, Wahbeh L, Salah S, Abuhijlih R, Abuhijla F. Turning the tide: From cervical cancer's grip to complete response: A case report. World J Clin Oncol 2025; 16(2): 98219 [DOI: 10.5306/wjco.v16.i2.98219]
Corresponding Author of This Article
Fawzi Abuhijla, MD, MSc, Assistant Professor, Department of Radiation Oncology, King Hussein Cancer Center, Queen Rania St. PO Box 1269, Amman 11941, Jordan. fhijle@khcc.jo
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Feb 24, 2025; 16(2): 98219 Published online Feb 24, 2025. doi: 10.5306/wjco.v16.i2.98219
Turning the tide: From cervical cancer's grip to complete response: A case report
Shatha Abutaha, Abdulla Alzibdeh, Issa Mohamad, Lina Wahbeh, Samer Salah, Ramiz Abuhijlih, Fawzi Abuhijla
Shatha Abutaha, Abdulla Alzibdeh, Issa Mohamad, Lina Wahbeh, Ramiz Abuhijlih, Fawzi Abuhijla, Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan
Samer Salah, Department of Medical Oncology, King Fahad Specialist Hospital, Dammam 32210, Saudi Arabia
Author contributions: Abutaha S and Abuhijla F designed the overall concept and outline of the manuscript; Abutaha S and Abuhijla F contributed data collection and review of literature; all authors contributed to the writing, editing and final approval of the manuscript. All authors believe that this manuscript will add useful information to the existing literature.
Informed consent statement: Written informed consent was obtained from the patient before writing this case report. She was provided with detailed information regarding the purpose and benefits of the paper, and was assured that her identity would remain confidential and that all efforts would be made to protect her privacy throughout the publication process.
Conflict-of-interest statement: All authors declare no conflict of interest related to the material discussed in this manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fawzi Abuhijla, MD, MSc, Assistant Professor, Department of Radiation Oncology, King Hussein Cancer Center, Queen Rania St. PO Box 1269, Amman 11941, Jordan. fhijle@khcc.jo
Received: June 20, 2024 Revised: September 24, 2024 Accepted: October 25, 2024 Published online: February 24, 2025 Processing time: 173 Days and 21.1 Hours
Abstract
BACKGROUND
Cervical cancer is a formidable global health issue, particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines, screening programs, and treatment modalities. The case report presents a unique case of a large cervical cancer achieving complete response (CR) with concurrent chemoradiotherapy (CCRT), highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy (RT) in optimizing patient outcomes.
CASE SUMMARY
We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive, moderately differentiated cervical squamous cell carcinoma. The tumor measured 14 cm × 12 cm × 8 cm, the largest size reported in the literature to achieve CR with CCRT. Despite this monumental feat, the patient remained disease-free and is currently on follow-up for 2 years; however, she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis, underscoring the continuing impact of cervical cancer on quality of life.
CONCLUSION
In this case report, we highlight the effectiveness of CCRT in achieving CR, even in cases of bulky cervical cancer, with adaptive RT offering a customized strategy to improve patient outcomes. We also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.
Core Tip: In this report, we highlight the effectiveness of chemoradiation in achieving complete response, even in cases of bulky cervical cancer with the largest primary tumor reported in the literature, using adaptive radiotherapy offering a customized strategy to improve patient outcomes.
