Cassell A, Konneh S. Unlocking the potential-vitamin D in prostate cancer prevention. World J Clin Oncol 2024; 15(2): 169-174 [PMID: 38455136 DOI: 10.5306/wjco.v15.i2.169]
Corresponding Author of This Article
Ayun Cassell, FACS, FICS, Assistant Professor, Senior Researcher, Surgeon, Division of Urology, Department of Surgery, John F Kennedy Medical Center, Sinkor, Monrovia 100010, Liberia. ayuncasselliii@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Feb 24, 2024; 15(2): 169-174 Published online Feb 24, 2024. doi: 10.5306/wjco.v15.i2.169
Unlocking the potential-vitamin D in prostate cancer prevention
Ayun Cassell, Solomane Konneh
Ayun Cassell, Solomane Konneh, Division of Urology, Department of Surgery, John F Kennedy Medical Center, Monrovia 100010, Liberia
Author contributions: Cassell A and Konneh S have equally contributed to the drafting and design of this manuscript; All authors have read and approve the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ayun Cassell, FACS, FICS, Assistant Professor, Senior Researcher, Surgeon, Division of Urology, Department of Surgery, John F Kennedy Medical Center, Sinkor, Monrovia 100010, Liberia. ayuncasselliii@gmail.com
Received: December 3, 2023 Peer-review started: December 3, 2023 First decision: December 18, 2023 Revised: December 19, 2023 Accepted: January 24, 2024 Article in press: January 24, 2024 Published online: February 24, 2024 Processing time: 78 Days and 9 Hours
Abstract
Prostate cancer poses a significant health challenge globally, demanding proactive prevention strategies. This editorial explores the emerging role of vitamin D in prostate cancer prevention. While traditionally associated with bone health, vitamin D is increasingly recognized for its broader impact on immune function, cellular signaling, and cancer prevention. Epidemiological studies suggest an intriguing link between vitamin D deficiency and elevated prostate cancer risk, particularly in regions with limited sunlight exposure. Mechanistically, vitamin D regulates cellular processes, inhibiting unchecked cancer cell growth and bolstering immune surveillance. Personalized prevention strategies, considering individual factors, are deemed essential for harnessing the full potential of vitamin D. To unlock this potential, the future calls for robust research, public awareness campaigns, dietary improvements, and vigilant medical guidance. Collaborative efforts are poised to pave the way toward a future where vitamin D stands as a sentinel in prostate cancer prevention, ushering in hope and improved health for men worldwide.
Core Tip: This editorial highlights the evolving role of vitamin D in prostate cancer prevention, going beyond its traditional association with bone health. Emerging evidence suggests a link between vitamin D deficiency and increased prostate cancer risk, especially in regions with limited sunlight exposure. Mechanistically, vitamin D regulates cellular processes, inhibiting cancer cell growth and enhancing immune surveillance. To unlock its full potential, personalized prevention strategies are crucial. Robust research, public awareness, dietary improvements, and vigilant medical guidance are essential components. Collaborative efforts aim to position vitamin D as a sentinel in prostate cancer prevention, offering hope and improved health for men globally.
