Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Oct 24, 2024; 15(10): 1376-1378
Published online Oct 24, 2024. doi: 10.5306/wjco.v15.i10.1376
Dysbiosis and colonic adenoma: The lethal link?
Krishna Kumar Govindarajan
Krishna Kumar Govindarajan, Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Author contributions: Govindarajan KK was responsible for prepared and updated the manuscript.
Conflict-of-interest statement: No conflict of interest declared.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Krishna Kumar Govindarajan, FACS, MBBS, MCh, MNAMS, MS, Professor, Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri Nagar, Pondicherry 605006, India. sasisang@rediffmail.com
Received: July 3, 2024
Revised: July 24, 2024
Accepted: August 26, 2024
Published online: October 24, 2024
Processing time: 87 Days and 18.3 Hours
Abstract

Gut dysbiosis, a phenomenon in which the existing commensal microbiome changes to an adverse microenvironment in the colon, is thought to lead to altered cellular signals. How this is involved in producing mucosal outgrowths such as polyps in the colon is intriguing. Deciphering the various mechanisms involved provides an in-depth understanding of the link between gut dysbiosis and colonic polyps.

Keywords: Dysbiosis; Adenoma; Polyp; Gut; Microbiota

Core Tip: It is fascinating to note that the gut microbiota can be the basis for the repeated occurrence of gut pathologies such as colonic polyps. Elucidating the various mechanisms involved would provide greater insights into the problem of colonic polyps.