Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Oct 24, 2024; 15(10): 1264-1268
Published online Oct 24, 2024. doi: 10.5306/wjco.v15.i10.1264
Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment
Mesut Tez
Mesut Tez, Department of Surgery, University of Health Sciences, Ankara City Hospital, Ankara 06800, Türkiye
Author contributions: Tez M wrote the manuscript.
Conflict-of-interest statement: There is no conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mesut Tez, MD, Chief Physician, Department of Surgery, University of Health Sciences, Ankara City Hospital, No. 1 Bilkent Street, District of Universities, Ankara 06800, Türkiye. mesuttez@yahoo.com
Received: July 25, 2024
Revised: August 25, 2024
Accepted: August 28, 2024
Published online: October 24, 2024
Processing time: 65 Days and 15.2 Hours
Abstract

The prognosis of colorectal cancer (CRC) patients with peritoneal metastasis remains poor despite advancements in detection and treatment. Preoperative inflammatory and nutritional markers have emerged as significant predictors of prognosis in CRC, potentially guiding treatment decisions and improving patient outcomes. This editorial explores the prognostic value of markers such as the neutrophil-to-lymphocyte ratio, hemoglobin, and serum albumin levels. By integrating these markers into prognostic models, clinicians can better stratify patients, personalize treatment strategies, and ultimately enhance clinical outcomes. This review highlights the importance of these markers in providing a comprehensive assessment of patient condition and underscores the need for further research to validate their clinical utility and uncover underlying mechanisms.

Keywords: Colorectal cancer; Peritoneal metastasis; Neutrophil-to-lymphocyte ratio; Hemoglobin; Serum albumin; Inflammatory markers; Nutritional markers; Prognosis; Preoperative markers; Personalized treatment

Core Tip: This editorial highlight the prognostic significance of preoperative inflammatory and nutritional markers, such as neutrophil-to-lymphocyte ratio, hemoglobin, and serum albumin, in colorectal cancer with peritoneal metastasis. By integrating these markers into prognostic models, we can improve the accuracy of prognosis prediction, guide personalized treatment strategies, and optimize patient outcomes. This comprehensive review underscores the need for further research to validate these findings and explore underlying mechanisms, ultimately enhancing the management of colorectal cancer.