Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2023; 14(12): 549-569
Published online Dec 24, 2023. doi: 10.5306/wjco.v14.i12.549
Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy
Hao-Ling Zhang, Doblin Sandai, Zhong-Wen Zhang, Zhi-Jing Song, Dinesh Babu, Yasser Tabana, Sabbar Saad Dahham, Mowaffaq Adam Ahmed Adam, Yong Wang, Wei Wang, Hao-Long Zhang, Rui Zhao, Khaled Barakat, Mohammad Syamsul Reza Harun, Siti Nurfatimah Mohd Shapudin, Bronwyn Lok
Hao-Ling Zhang, Doblin Sandai, Hao-Long Zhang, Mohammad Syamsul Reza Harun, Siti Nurfatimah Mohd Shapudin, Bronwyn Lok, Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, Penang 13200, Malaysia
Zhong-Wen Zhang, School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Zhi-Jing Song, Rui Zhao, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Dinesh Babu, Yasser Tabana, Khaled Barakat, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton AB T6G 2E1, Canada
Sabbar Saad Dahham, Department of Science, University of Technology and Applied Sciences Rustaq, Rustaq 10 P.C. 329, Oman
Mowaffaq Adam Ahmed Adam, Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, United States
Yong Wang, Pathology Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Wei Wang, College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Co-corresponding authors: Doblin Sandai and Zhi-Jing Song.
Author contributions: Zhang HL presented the conceptualization and methodology, analyzed the data, and wrote the first draft; Zhang ZW, Song ZJ, Babu D, Tabana Y, Dahham SS, Adam Ahmed Adam M, Wang Y, and Wang W presented the conceptualization and methodology, analyzed the data, and conducted the review and editing; Zhang HL, Zhao R, Barakat K, Harun MSR, Shapudin SNM and Lok B collected and collated the data and produced a visual atlas; Sandai D presents the conceptualization and methodology, revises manuscripts, conducts reviews and edits, and is responsible for project management; Zhang HL presented the conceptualization and methodology, analyzed the data, and wrote the first draft; Zhang ZW, Song ZJ, Babu D, Tabana Y, Dahham SS, Adam Ahmed Adam M, Wang Y, and Wang W presented the conceptualization and methodology, analyzed the data, and conducted the review and editing; Zhang HL, Zhao R, Barakat K, Harun MSR, Shapudin SNM and Lok B collected and collated the data and produced a visual atlas; Sandai D presents the conceptualization and methodology, revises manuscripts, conducts reviews and edits, and is responsible for project management; both Sandai D and Song ZJ give detailed guidance to this paper, which is of great significance. Therefore, as a co-corresponding author; all authors have read and approve the final manuscript.
Supported by National Natural Science Foundation of China, No. 81960877; University Innovation Fund of Gansu Province, No. 2021A-076; Gansu Province Science and Technology Plan (Innovation Base and Talent Plan), No. 21JR7RA561; Natural Science Foundation of Gansu Province, No. 21JR1RA267 and No. 22JR5RA582; Education Technology Innovation Project of Gansu Province, No. 2022A-067; Innovation Fund of Higher Education of Gansu Province, No. 2023A-088; Gansu Province Science and Technology Plan International Cooperation Field Project, No. 23YFWA0005.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Doblin Sandai, Doctor, PhD, Academic Editor, Researcher, Department of Biomedical Sciences, Advanced Medical and Dental Institute, University Sains Malaysia, Kepala Batas, Penang 13200, Malaysia. doblin@usm.my
Received: September 6, 2023
Peer-review started: September 6, 2023
First decision: October 24, 2023
Revised: November 8, 2023
Accepted: November 21, 2023
Article in press: November 21, 2023
Published online: December 24, 2023
Processing time: 107 Days and 1.9 Hours
Abstract

Adenosine triphosphate (ATP) induced cell death (AICD) is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions. This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology. This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer. This is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis, deciphering the intricate mechanisms governing AICD, elucidating its intricate involvement in cancer signaling pathways, and scrutinizing validated key genes. Moreover, the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.

Keywords: Adenosine triphosphate induced cell death; Adenosine triphosphate homeostasis; Mechanism; Cancer signaling pathways; Prognosis and clinical values; Cancer treatment

Core Tip: The research delves deeply into the pivotal realm of adenosine triphosphate (ATP)-induced cell death (AICD), a fundamental cellular phenomenon that has captured significant scholarly interest owing to its pertinence in cancer biology and therapeutic strategies. Our review is dedicated to delivering an all-encompassing grasp of the intricate mechanisms underpinning AICD and its far-reaching ramifications within the cancer context. By meticulously dissecting the dynamic interplay between systemic and cellular ATP homeostasis, unraveling the governing mechanisms steering AICD, and probing its intricate entanglement with cancer signaling pathways, we present an exhaustive framework that illuminates the multifaceted role of AICD in the realm of cancer.