Hu ZX, Tan MH, Li QZ, Xu JL, Chen W, Xie ZH, Zhou YJ, Liang Q, An JH, Shen H. Endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor: A case report. World J Clin Oncol 2020; 11(12): 1076-1083 [PMID: 33437669 DOI: 10.5306/wjco.v11.i12.1076]
Corresponding Author of This Article
Hong Shen, PhD, Chief Doctor, Department of Pathology, Southern Medical University, Shatai South Road, Baiyun District, Guangzhou 510515, Guangdong Province, China. shenhong2010168@163.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Dec 24, 2020; 11(12): 1076-1083 Published online Dec 24, 2020. doi: 10.5306/wjco.v11.i12.1076
Endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor: A case report
Zhi-Xiong Hu, Min-Hua Tan, Qiong-Zhen Li, Jia-Li Xu, Wei Chen, Zhi-Hao Xie, Yong-Jian Zhou, Qing Liang, Jian-Hong An, Hong Shen
Zhi-Xiong Hu, Min-Hua Tan, Wei Chen, Zhi-Hao Xie, Yong-Jian Zhou, Qing Liang, Department of Pathology, The First People’s Hospital of Zhaoqing, Zhaoqing 526020, Guangdong Province, China
Qiong-Zhen Li, Department of Gynaecology and Obstetrics, The First People’s Hospital of Zhaoqing, Zhaoqing 526020, Guangdong Province, China
Jia-Li Xu, Department of Radiology, The First People’s Hospital of Zhaoqing, Zhaoqing 526020, Guangdong Province, China
Jian-Hong An, School of Medicine, South China University of Technology, Guangzhou 510006, Guangdong Province, China
Hong Shen, Department of Pathology, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Hu ZX contributed to pathological diagnosis, collecting the patient's medical records and pathological pictures, and writing the first draft of the paper; Tan MH contributed to pathological diagnosis and data management; Li QZ performed the surgery; Xu JL performed B-ultrasound examination; Chen W contributed to gross specimen picture arrangement; Xie ZH contributed to taking the pathological biopsy and taking photos; Zhou YJ contributed to H&E staining; Liang Q contributed to immunohistochemical staining; An JH contributed to translation and submission of the paper; Shen H contributed to study design, data analysis, conclusion extraction, and guiding paper writing, modification, and finalization.
Informed consent statement: The patient provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong Shen, PhD, Chief Doctor, Department of Pathology, Southern Medical University, Shatai South Road, Baiyun District, Guangzhou 510515, Guangdong Province, China. shenhong2010168@163.com
Received: August 21, 2020 Peer-review started: August 21, 2020 First decision: September 13, 2020 Revised: September 27, 2020 Accepted: October 15, 2020 Article in press: October 15, 2020 Published online: December 24, 2020 Processing time: 119 Days and 6.8 Hours
Abstract
BACKGROUND
To investigate the clinicopathological features of endometrial clear cell carcinoma that has invaded the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor.
CASE SUMMARY
A case of endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor was collected and analyzed using pathomorphology and immunohistochemistry. Endometrial clear cell carcinoma cells were distributed in a solid nest, papillary, shoe nail-like, and glandular tube-like distribution. There was infiltrative growth, and tumor cells had clear cytoplasm and obvious nuclear heteromorphism. The cancer tissue was necrotic and mitotic. The cancer tissue invaded the right oviduct. The ipsilateral oviduct also had an adenomatoid tumor. The adenomatoid tumor was arranged in microcapsules lined with flat or cubic cells that were surrounded by smooth muscle tissue. The adenomatoid tumor cells were round in shape.
CONCLUSION
Clear cell carcinoma of the endometrium can invade the oviduct and occur simultaneously with tubal adenomatoid tumors. Upon pathological diagnosis, one should pay close attention to distinguishing whether an endometrial clear cell carcinoma is invading the oviduct or whether it is accompanied by an adenomatoid tumor of the oviduct. Immunohistochemistry is helpful to differentiate these two disease entities. Endometrial clear cell carcinomas express Napsin-A and P16 and are negative for estrogen receptor and progesterone receptor. The presence of endometrial clear cell carcinoma does not affect the expression of CK and calretinin in adenomatoid tumors.
Core Tip: In pathological diagnosis, when investigating invasion of the oviduct, one should pay close attention to distinguishing whether the endometrial clear cell carcinoma invades the oviduct or whether it is accompanied by an oviduct adenomatoid tumor. The significance of this investigation is to determine whether the endometrial adenocarcinoma has tubal metastasis. This is critical for the confirmation of T3a in tumor-node-metastasis staging.
