Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2019; 10(4): 192-200
Published online Apr 24, 2019. doi: 10.5306/wjco.v10.i4.192
Dentinogenic ghost cell tumor: A case report
Sangeeta R Patankar, Palak Khetan, Sheetal K Choudhari, Harshal Suryavanshi
Sangeeta R Patankar, Palak Khetan, Sheetal K Choudhari, Department of Oral Pathology and Microbiology, Yerala Medical Trust’s Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India
Harshal Suryavanshi, Department of Oral and Maxillofacial Surgery, Yerala Medical Trust’s Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India
Author contributions: Patankar SR and Khetan P contributed equally to this work; Patankar SR, Khetan P, Choudhari SK and Suryavanshi H designed the case report; Patankar SR, Khetan P and Choudhari SK drafted the case report; Patankar SR, Khetan P, Choudhari SK and Suryavanshi H analyzed the case; Patankar SR, Khetan P, Choudhari SK and Suryavanshi H wrote the manuscript. All authors have read and approve the final manuscript. All authors contributed equally to the acquisition of case, writing, and revision of this manuscript.
Informed consent statement: The patient reported in this study gave informed consent authorizing use and disclosure of his protected health information.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Palak Khetan, MD, Doctor, Department of Oral Pathology and Microbiology, Yerala Medical Trust’s Dental College and Hospital, Institutional area, Sector-4, Kharghar, Navi Mumbai 410210, Maharashtra, India. drpalak.ymtdc@gmail.com
Telephone: +91-022-27744429 Fax: +91-022-27744427
Received: August 9, 2018
Peer-review started: August 9, 2018
First decision: October 5, 2018
Revised: March 15, 2019
Accepted: April 8, 2019
Article in press: April 9, 2019
Published online: April 24, 2019
Processing time: 258 Days and 10.5 Hours
Abstract
BACKGROUND

Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive odontogenic neoplasm. It is considered to be a solid variant of calcifying odontogenic cyst (COC). This tumor makes up for only 2%-14% of all COCs and less than 0.5% of all odontogenic tumors which owes to its rarity. The purpose of this paper was to describe a case of DGCT and the treatment adopted in our case, and to provide a review of this case in the indexed literature.

CASE SUMMARY

In this article, we discussed a case of 18 year old male who reported with a chief complaint of a recurrent swelling and dull aching pain in upper left back region of the jaw. Computed tomography scan was carried out which revealed hypodense lesion with a few hyperdense flecks within it suggesting the presence of calcification. On incisional biopsy, diagnosis of COC was given. After segmental resection of the lesion, histopathogically odontogenic epithelium was noted along with calcifications, ghost cells and dentinoid material. Special staining was done with van Gieson and it showed pink areas of dentinoid material and yellow colour represented ghost cells. Hence, amalgamation of careful clinical examination, use of advanced radiographic imaging and detailed histopathological examination confirmed the diagnosis of DGCT. The patient was followed up for one year and there was no recurrence of the lesion or signs of any residual tumor.

CONCLUSION

Radical treatment should be carried out along with mandatory long-term follow up in order to avoid recurrence in aggressive lesions.

Keywords: Dentinoid; Ghost cells; Calcifying odontogenic cyst; Dentinogenic ghost cell tumor; Case report; Van Gieson

Core tip: There is diversity in the differential diagnosis of a variety of odontogenic cysts and tumors. A detailed case history, use of advanced radiographic imaging techniques and appropriate histopathological examination remains the mainstay for accurate diagnosis and treatment planning of a lesion. Adequate surgical intervention is required for aggressive lesions like dentinogenic ghost cell tumor. Treatment with enucleation might lead to recurrence of this tumor. Hence, patients should be treated with more radical approach and should be kept on long- term follow up.