Copyright
©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Dec 5, 2018; 9(6): 55-62
Published online Dec 5, 2018. doi: 10.4292/wjgpt.v9.i6.55
Published online Dec 5, 2018. doi: 10.4292/wjgpt.v9.i6.55
Coeliac disease in the modern era: Severity of small bowel mucosal injury at diagnosis with analysis of clinical correlates and rate of improvement on a gluten free diet
Oliver Cronin, Damian Dowling, Department of Gastroenterology, University Hospital Geelong, Geelong 3220, Australia
Emma Flanagan, Department of Gastroenterology, St Vincent’s Hospital, Fitzroy 3065, Australia
Author contributions: Dowling D designed the research and critically revised the manuscript; Flanagan E collected the data; Cronin O analyzed the data and wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Barwon Health Human Research Ethics Committee (Geelong, Australia).
Conflict-of-interest statement: There are no conflicts of interest to report.
STROBE statement: Guidelines from the STROBE statement have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Oliver Cronin, MBBS, Doctor, Department of Gastroenterology, University Hospital Geelong, Ryrie St & Bellerine St, Geelong 3220, Australia. oliver.cronin@barwonhealth.org.au
Telephone: +61-3-42150000 Fax: +61-3-42150000
Received: May 25, 2018
Peer-review started: May 25, 2018
First decision: June 13, 2018
Revised: July 9, 2018
Accepted: July 21, 2018
Article in press: July 21, 2018
Published online: December 5, 2018
Peer-review started: May 25, 2018
First decision: June 13, 2018
Revised: July 9, 2018
Accepted: July 21, 2018
Article in press: July 21, 2018
Published online: December 5, 2018
Core Tip
Core tip: Coeliac disease (CD) is a common, under-recognized gastrointestinal disorder. The findings in this study support other larger studies which have reported a trend toward an asymptomatic or silent presentation of CD. Thyroid related autoimmune co-morbidities were common (n = 17, 17%). Symptoms at presentation were not associated with the degree of villous blunting on biopsy. Similarly, persistent villous blunting at repeat biopsy was not associated with symptoms or positive coeliac serology. Negative coeliac serology did not exclude ongoing mucosal injury.