Emile SH, Elfeki HA, Elbanna HG, Youssef M, Thabet W, Abd El-Hamed TM, Said B, Lotfy A. Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review. World J Gastrointest Pharmacol Ther 2016; 7(3): 453-462 [PMID: 27602248 DOI: 10.4292/wjgpt.v7.i3.453]
Corresponding Author of This Article
Sameh Hany Emile, MD, Lecturer of General Surgery, General Surgery Department, Colorectal Surgery Unit, Mansoura Faculty of Medicine, Mansoura University, Elgomhuoria Street, Mansoura City 35516, Dakahlia Providence, Egypt. sameh200@hotmail.com
Research Domain of This Article
Surgery
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 453-462 Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.453
Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review
Sameh Hany Emile, Hossam Ayman Elfeki, Hosam Ghazy Elbanna, Mohamed Youssef, Waleed Thabet, Tito M Abd El-Hamed, Basem Said, Ahmed Lotfy
Sameh Hany Emile, Hossam Ayman Elfeki, Hosam Ghazy Elbanna, Mohamed Youssef, Waleed Thabet, Tito M Abd El-Hamed, Basem Said, Ahmed Lotfy, General Surgery Department, Colorectal Surgery Unit, Mansoura Faculty of Medicine, Mansoura University, Mansoura City 35516, Dakahlia Providence, Egypt
Author contributions: Emile SH designed the review; Emile SH and Elfeki HA conducted the search and acquisition and analysis of data; Emile SH, Elfeki HA and Youssef M wrote the manuscript; Elbanna HG, Abd El-Hamed TM and Said B contributed to data interpretation, writing and critical revision of the manuscript; Thabet W, Said B and Lotfy A shared in data analysis, drafting and critical revision of the manuscript; all authors approved the final version of the manuscript.
Conflict-of-interest statement: All the authors declare that they have no competing interests.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at sameh200@hotmail.com. Informed consents of patients were obtained by the original studies included in the review.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sameh Hany Emile, MD, Lecturer of General Surgery, General Surgery Department, Colorectal Surgery Unit, Mansoura Faculty of Medicine, Mansoura University, Elgomhuoria Street, Mansoura City 35516, Dakahlia Providence, Egypt. sameh200@hotmail.com
Telephone: +20-100-6267150 Fax: +20-50-239733
Received: February 29, 2016 Peer-review started: February 29, 2016 First decision: June 16, 2016 Revised: June 20, 2016 Accepted: July 11, 2016 Article in press: July 13, 2016 Published online: August 6, 2016 Processing time: 154 Days and 7.3 Hours
Core Tip
Core tip: Injection of botulinum toxin type A (BTX-A) is a simple, technically feasible outpatient procedure. The initial satisfactory improvement of symptoms after BTX-A injection remarkably deteriorates after three months of the procedure from a median rate of 77.4% to 46%. However, repeated injections may provide better sustained results with no additional morbidities. The endorectal ultrasonography- and electromyography-guided techniques do not add significant value regarding both initial and long-term improvement. Combined lateral and posterior injections do not offer better results than lateral injection alone, on the contrary they can lead to higher complication rates. Although most of the studies reported very low complication rates after BTX-A injection; further studies on a larger number of patients are necessary to conclude the safety of this treatment.
