Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 434-439
Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.434
Incidence of leukopenia after intraperitoneal vs combined intravenous/intraperitoneal chemotherapy in pseudomyxoma peritonei
Philipp Horvath, Stefan Beckert, Florian Struller, Alfred Königsrainer, Ingmar Königsrainer
Philipp Horvath, Stefan Beckert, Florian Struller, Alfred Königsrainer, Ingmar Königsrainer, Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center, 72076 Tübingen, Germany
Author contributions: Horvath P designed and performed the research and wrote the paper; Beckert S performed the statistical analysis and supervised the report; Struller F contributed to the research; Königsrainer A supervised the report; Königsrainer I interpreted the data, supervised the report and made the final revision of the paper.
Institutional review board statement: We confirm that retrospective data collection and dealing with personal data was conducted in accordance to the guidelines of the local ethics committee.
Informed consent statement: We confirm that all patients gave written or oral informed consent prior to their inclusion.
Conflict-of-interest statement: We declare that we have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ingmar Königsrainer, MD, Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany. koenigsrainer@med.uni-tuebingen.de
Telephone: +49-7071-2986620 Fax: +49-7071-295588
Received: February 12, 2016
Peer-review started: February 12, 2016
First decision: March 18, 2016
Revised: March 18, 2016
Accepted: May 10, 2016
Article in press: May 11, 2016
Published online: August 6, 2016
Processing time: 139 Days and 11.1 Hours
Core Tip

Core tip: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) are considered the therapy of choice for patients with pseudomyxoma peritonei. Nevertheless this treatment is a major undertaking associated with elevated morbidity. The occurrence of postoperative leukopenia can deteriorate the patient’s outcome by triggering complications like anastomotic insufficiencies or intraabdominal abscess formations so that surgeons must be aware that special patient subsets (primarily older patients and females) exist that are at a higher risk for developing post-HIPEC leukopenia.