Toledo de Arruda Lourenção PL, Terra SA, Ortolan EVP, Rodrigues MAM. Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation. World J Gastrointest Pharmacol Ther 2016; 7(3): 397-405 [PMID: 27602240 DOI: 10.4292/wjgpt.v7.i3.397]
Corresponding Author of This Article
Pedro Luiz Toledo de Arruda Lourenção, Professor of Pediatric Surgery, Department of Surgery and Orthopedics, Botucatu Medical School - Unesp, Av. Prof. Montenegro, Distrito de Rubião Junior, s/n, Botucatu, São Paulo 18618-687, Brazil. lourencao@fmb.unesp.br
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 397-405 Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.397
Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation
Pedro Luiz Toledo de Arruda Lourenção, Simone Antunes Terra, Erika Veruska Paiva Ortolan, Maria Aparecida Marchesan Rodrigues
Pedro Luiz Toledo de Arruda Lourenção, Erika Veruska Paiva Ortolan, Department of Surgery and Orthopedics, Botucatu Medical School - Unesp, Botucatu, São Paulo 18618-687, Brazil
Simone Antunes Terra, Maria Aparecida Marchesan Rodrigues, Department of Pathology, Botucatu Medical School - Unesp, Botucatu, São Paulo 18618-687, Brazil
Author contributions: Toledo de Arruda Lourenção PL analysed and interpretated the data, drafted the initial manuscript and revised the article critically; Terra SA performed the collected the data and draft the initial manuscript; Ortolan EVP draft the initial manuscript; Rodrigues MAM analysed and interpreted the data, drafted the initial manuscript and revised critically.
Supported bySão Paulo Research Foundation (FAPESP), No. 2014/042271-1.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pedro Luiz Toledo de Arruda Lourenção, Professor of Pediatric Surgery, Department of Surgery and Orthopedics, Botucatu Medical School - Unesp, Av. Prof. Montenegro, Distrito de Rubião Junior, s/n, Botucatu, São Paulo 18618-687, Brazil. lourencao@fmb.unesp.br
Telephone: +55-14-38801703 Fax: +55-14-38801669
Received: February 14, 2016 Peer-review started: February 15, 2016 First decision: March 31, 2016 Revised: April 14, 2016 Accepted: May 7, 2016 Article in press: May 9, 2016 Published online: August 6, 2016 Processing time: 168 Days and 15.9 Hours
Core Tip
Core tip: Intestinal neuronal dysplasia type B (IND-B) is a controversial entity among the gastrointestinal neuromuscular disorders. Chronic constipation is the most common clinical manifestation of patients. IND-B primarily affects young children and mimics Hirschsprung’s disease, but has its own histopathologic features characterized mainly by hyperplasia of the submucosal nerve plexus. Despite the intense scientific research in the last decades, there are still knowledge gaps regarding IND-B. This review critically discusses aspects related to the disease definitions, pathophysiology and genetics, epidemiology distribution, clinical presentation, diagnostic criteria and therapeutic possibilities of this still little-known organic cause of intestinal chronic constipation.
