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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 353-360
Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.353
Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.353
Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases
Imene Soufli, Ryma Toumi, Hayet Rafa, Chafia Touil-Boukoffa, Department of Cellular and Molecular Biology, University of Sciences and Technology Houari Boumediene, 16111 Algiers, Algeria
Author contributions: Soufli I analyzed the literature, wrote, submitted and edited the manuscript; Toumi R and Touil-Boukoffa C analyzed the literature and wrote the manuscript; Rafa H analysed and wrote a part of the manuscript.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chafia Touil-Boukoffa, Professor, Department of Cellular and Molecular Biology, University of Sciences and Technology Houari Boumediene, El alia, Bab Ezzouar, BP 32, 16111 Algiers, Algeria. touilboukoffa@yahoo.fr
Telephone: +213-550-819857
Received: March 29, 2016
Peer-review started: April 5, 2016
First decision: May 23, 2016
Revised: June 10, 2016
Accepted: July 14, 2016
Article in press: July 18, 2016
Published online: August 6, 2016
Processing time: 125 Days and 2 Hours
Peer-review started: April 5, 2016
First decision: May 23, 2016
Revised: June 10, 2016
Accepted: July 14, 2016
Article in press: July 18, 2016
Published online: August 6, 2016
Processing time: 125 Days and 2 Hours
Core Tip
Core tip: Inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis are an immunolgically mediated disease with undetermined etiology. Evidence from animal and clinical studies demonstrate a positive correlation between an increased concentration of nitric oxide (NO) and the severity of the disease. Moreover, a positive correlation between NO production and increased pro-inflammatory cytokine levels [tumor necrosis factor-α, interleukin (IL)-6, IL-17, IL-12, and interferon-γ] were reported in patients with IBD. This review focuses on the role of cytokines in intestinal inflammation and their relationship with NO in IBD.