Editorial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Nov 6, 2015; 6(4): 120-126
Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.120
Role of peroxisome proliferator-activated receptors alpha and gamma in gastric ulcer: An overview of experimental evidences
Lekha Saha
Lekha Saha, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Author contributions: Saha L, the sole author of the manuscript, conceived the issues which formed the content of the manuscript and wrote the manuscript.
Conflict-of-interest statement: None declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lekha Saha, Associate Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. lekhasaha@rediffmail.com
Telephone: +91-172-2755253 Fax: +91-172-2744401
Received: April 15, 2015
Peer-review started: April 18, 2015
First decision: June 18, 2015
Revised: July 11, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: November 6, 2015
Processing time: 211 Days and 2.4 Hours
Core Tip

Core tip: Peroxisome proliferator-activated receptors (PPARs) are a nuclear hormone receptor family and act as transcription factors. PPARs are of three subtypes, i.e., PPARα, PPARβ/δ, and PPARγ. The common sites where PPARα is expressed are muscle, heart, liver, small intestine and kidney. PPARγ is involved in modulation of various functions like inflammation, cell proliferation, and differentiation and it is commonly expressed in white blood cells (e.g., macrophages and monocytes) which are involved in immune activity and in the colon. Studies in animals have demonstrated the gastric antisecretory activity of PPARα agonists like ciprofibrate, bezafibrate and clofibrate. The majority of the experimental studies regarding the role of PPARγ activators is on pioglitazone and rosiglitazone. In all the studies, both the PPARγ activators showed protection against the gastric ulcer and also accelerate the ulcer healing in gastric ulcer model in rats. Therefore, PPARα and PPARγ can be explored as a target of gastric ulcer treatment. The aim of the present paper is to discuss the experimental evidences of the role of PPARs in gastric ulcer.