Case Report
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World J Gastrointest Pharmacol Ther. Aug 6, 2014; 5(3): 196-199
Published online Aug 6, 2014. doi: 10.4292/wjgpt.v5.i3.196
Rhabdomyolysis after midazolam administration in a cirrhotic patient treated with atorvastatin
Antonietta Gigante, Gianluca Di Lazzaro Giraldi, Maria Ludovica Gasperini, Biagio Barbano, Marta Liberatori, Liborio Sardo, Francesca Di Mario, Antonella Giorgi, Filippo Rossi-Fanelli, Antonio Amoroso
Antonietta Gigante, Gianluca Di Lazzaro Giraldi, Maria Ludovica Gasperini, Biagio Barbano, Marta Liberatori, Liborio Sardo, Francesca Di Mario, Antonella Giorgi, Filippo Rossi-Fanelli, Antonio Amoroso, Department of Clinical Medicine, “Sapienza” University of Rome, 00185 Rome, Italy
Author contributions: All authors contributed to this manuscript.
Correspondence to: Antonietta Gigante, MD, Department of Clinical Medicine, “Sapienza” University of Rome, Viale dell’Università n 37, 00185 Rome, Italy. antonietta_gigante@yahoo.it
Telephone: +39-6-49972074 Fax: +39-6-49972074
Received: March 6, 2014
Revised: May 5, 2014
Accepted: May 29, 2014
Published online: August 6, 2014
Processing time: 182 Days and 6.5 Hours
Core Tip

Core tip: When dealing with alcoholic liver disease, clinicians need to pay particular attention to the administration of drugs, their dosage, interactions and metabolism to avoid severe adverse reactions. Cirrhotic patients on treatment with statins (particularly atorvastatin) are at high risk of developing fatal rhabdomyolysis and acute renal failure when midazolam is used to allow gastric endoscopy.