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World J Gastrointest Pharmacol Ther. Aug 6, 2013; 4(3): 61-68
Published online Aug 6, 2013. doi: 10.4292/wjgpt.v4.i3.61
Published online Aug 6, 2013. doi: 10.4292/wjgpt.v4.i3.61
Outcome of patients with primary sclerosing cholangitis and ulcerative colitis undergoing colectomy
Sombat Treeprasertsuk, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Einar Björnsson, Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital of Iceland, IS121 Reykjavik, Iceland
Emmanouil Sinakos, Emma Weeding, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States
Keith D Lindor, Health Solutions, Arizona State University, AZ 85004, United States
Author contributions: Treeprasertsuk S designed study, interpreted data and wrote the manuscript; Treeprasertsuk S and Sinakos E collected data; Björnsson E, Weeding E and Lindor KD analyzed data; Björnsson E and Lindor KD revised the manuscript.
Supported by A Medical Research Scholarship from the Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital (Thai Red Cross Society, Bangkok, Thailand) to Treeprasertsuk S; A One-Year Research Scholarship from the Hellenic Association for the Study of the Liver to Sinakos E
Correspondence to: Sombat Treeprasertsuk, MD, PhD, Associate Professor, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama4 Road, Pathumwan District, Bangkok 10330, Thailand. battan5410@gmail.com
Telephone: +66-2-2564265 Fax: +66-2-2527839
Received: February 14, 2013
Revised: April 24, 2013
Accepted: May 8, 2013
Published online: August 6, 2013
Processing time: 168 Days and 2.6 Hours
Revised: April 24, 2013
Accepted: May 8, 2013
Published online: August 6, 2013
Processing time: 168 Days and 2.6 Hours
Core Tip
Core tip: To study the outcomes of primary sclerosing cholangitis (PSC) patients with ulcerative colitis (UC) undergoing colectomy. We identified 193 patients with PSC and UC undergoing colectomy at the Mayo Clinic (Rochester, MN, United States), between January 1, 1995 and December 31, 2008. Eighty-nine patients were excluded. Of the 2441 patients with PSC, 104 patients (4.3%) had UC and underwent colectomy and were included. The median age was 43.2 years. One third of patients with PSC and UC undergoing colectomy died or underwent liver transplantation within 2.6 years. PSC patients with lower platelet counts and lower albumin levels were significantly more likely to have a poorer outcome.