Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Jun 5, 2025; 16(2): 103232
Published online Jun 5, 2025. doi: 10.4292/wjgpt.v16.i2.103232
Nalbuphine vs sufentanil as effective analgesics for postoperative pain management in gastric cancer resection
Wei-Xiang Wang, Fu-Lin Dang, Ting-Ting Li, Yue Yu
Wei-Xiang Wang, Department of Infectious Disease Prevention and Control, Nanjing Municipal Center for Disease Control and Prevention, Nanjing 210003, Jiangsu Province, China
Fu-Lin Dang, Huangyuan County People's Hospital, Xining 810000, Qinghai Province, China
Ting-Ting Li, Department of Geriatrics, Xining Hospital of Traditional Chinese Medicine, Xining 810000, Qinghai Province, China
Yue Yu, School of Pharmacy and Fujian Center for New Drug Safety Evaluation, Fujian Medical University, Fuzhou 350013, Fujian Province, China
Co-first authors: Wei-Xiang Wang and Fu-Lin Dang.
Author contributions: Wang WX and Dang FL contributed to this paper; Wang WX, Dang FL, and Li TT contributed to the writing, and editing the manuscript, illustrations, and review of literature; Yu Y designed the overall concept and outline of the manuscript, contributed to the discussion and design of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Supported by National Natural Science Foundation of China, No. 82404612.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Yu, PhD, Associate Professor, School of Pharmacy and Fujian Center for New Drug Safety Evaluation, Fujian Medical University, No. 1 Xuefu North Road, New District, Fuzhou 350013, Fujian Province, China. yyu@fjmu.edu.cn
Received: November 25, 2024
Revised: February 26, 2025
Accepted: March 17, 2025
Published online: June 5, 2025
Processing time: 193 Days and 1.8 Hours
Core Tip

Core Tip: Enhanced recovery after surgery (ERAS) protocols emphasize optimal pain management while minimizing opioid-related complications. This editorial highlights the comparative efficacy and safety profile of nalbuphine vs sufentanil in postoperative pain management following radical gastrectomy. The study demonstrates nalbuphine's advantages in terms of pain control, reduced inflammatory response, and fewer adverse events. Particularly noteworthy is its potential role in multimodal analgesia within ERAS protocols, offering a promising alternative for optimizing postoperative recovery while minimizing opioid-related complications.