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World J Gastrointest Pharmacol Ther. Nov 5, 2024; 15(6): 97381
Published online Nov 5, 2024. doi: 10.4292/wjgpt.v15.i6.97381
Regression of hepatic fibrosis after pharmacological therapy for nonalcoholic steatohepatitis
Mohamed Abdel-Samiee, Essam Salah Ibrahim, Mohamed Kohla, Eman Abdelsameea, Mohsen Salama
Mohamed Abdel-Samiee, Mohamed Kohla, Eman Abdelsameea, Mohsen Salama, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt
Essam Salah Ibrahim, Department of Medicine, RCSI Medical University of Bahrain, Adliya 15503, Bahrain
Author contributions: Abdelsameea E designed the research; Abdel-Samiee M, Ibrahim ES, Kohla M, Abdelsameea E, and Salama M analyzed data; Abdel-Samiee M, Ibrahim ES, Kohla M, Abdelsameea E, Salama M contributed to writing the paper, drafting, and revising critically; Abdel-Samiee M, Ibrahim ES, Kohla M, Abdelsameea E, Salama M approved the final version of the manuscript for submission.
Conflict-of-interest statement: All authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eman Abdelsameea, MD, Full Professor, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt. eabdelsameea@liver-eg.org
Received: May 29, 2024
Revised: August 28, 2024
Accepted: September 23, 2024
Published online: November 5, 2024
Processing time: 148 Days and 5.3 Hours
Core Tip

Core Tip: Non-alcoholic fatty liver disease (NAFLD) global incidence is escalating significantly. NAFLD covers a range of liver conditions, from simple steatosis to the more severe form known as non-alcoholic steatohepatitis, which involves chronic liver inflammation and the transformation of hepatic stellate cells into myofibroblasts that generate excess extracellular matrix, leading to fibrosis. Hepatocyte ballooning is a key catalyst for fibrosis progression.