Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Nov 5, 2024; 15(6): 95532
Published online Nov 5, 2024. doi: 10.4292/wjgpt.v15.i6.95532
Protective effects of long term antiplatelet and anticoagulant therapy in hospitalized patients with inflammatory bowel disease
Madhav Changela, Sagar Pandey, Janak Bahirwani, Nishit Patel, Maulik Kaneriya, Sanket D Basida, Anish Shah, Rahul Thakur, Krishna Bodrya, Suruchi Jai Kumar Ahuja, Yecheskel Schneider
Madhav Changela, Sagar Pandey, Maulik Kaneriya, Department of Internal Medicine, One Brooklyn Health System/Interfaith Medical Center, Brooklyn, NY 11213, United States
Janak Bahirwani, Nishit Patel, Yecheskel Schneider, Department of Gastroenterology, St. Luke's University Health Network, Bethlehem, PA 18015, United States
Sanket D Basida, Department of Internal Medicine, University of Missouri, Columbia, MO 65212, United States
Anish Shah, Department of Internal Medicine, Bronxcare Health System, Bronx, NY 10457, United States
Rahul Thakur, Department of Internal Medicine, Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY 10461, United States
Krishna Bodrya, Department of Internal Medicine, Lehigh Valley Health Network, Easton, PA 18045, United States
Suruchi Jai Kumar Ahuja, Department of Data Sciences, Sarepta Therapeutics, Cambridge, MA 02124, United States
Author contributions: Changela M, Pandey S, Bahirwani J, Patel N contributed to conception and design; Changela M, Pandey S, Bahirwani J, Patel N, Kaneriya M, Basida SD, Shah A, Jai Kumar Ahuja S, and Thakur R contributed to provision, collection, assembly of data, and administrative support; Changela M, Pandey S, Bahirwani J, Patel N, Kaneriya M, Basida SD, and Schneider Y contributed to the review of the literature and drafting the manuscript; Changela M, Bahirwani J, and Schneider Y contributed to revision of key components of the manuscript and final approval of manuscript; Changela M, Pandey S, Bahirwani J, Patel N, Kaneriya M, Basida SD, Shah A, Thakur R, Jai Kumar Ahuja S, and Schneider Y are accountable for all aspects of the work.
Institutional review board statement: This study, utilizing the National Inpatient Sample Database, is exempt from full Institutional Review Board review as it involves secondary analysis of de-identified data collected for administrative purposes. The exemption is granted by federal regulations governing research involving publicly available data and poses minimal risk to subjects, maintaining their anonymity. No identifiable information was used, ensuring strict confidentiality. This exemption aligns with ethical standards and guidelines.
Informed consent statement: As patient data was de-identified, informed consent was not required before proceeding with the study.
Conflict-of-interest statement: The authors have no financial relationships or conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Madhav Changela, MD, Doctor, Department of Internal Medicine, One Brooklyn Health System/Interfaith Medical Center, 1545 Atlantic Av, Brooklyn, NY 11213, United States. changelamadhav@gmail.com
Received: April 12, 2024
Revised: August 25, 2024
Accepted: September 19, 2024
Published online: November 5, 2024
Processing time: 195 Days and 7.3 Hours
Core Tip

Core Tip: In this retrospective study, hospitalized inflammatory bowel disease (IBD) patients on long-term antiplatelet or anticoagulant therapy demonstrated benefits in terms of inpatient mortality, length of stay, and total hospitalization charges compared to those not on such therapy. While the use of anticoagulation alone or in combination with antiplatelet agents was linked to higher odds of lower gastrointestinal bleeding, there was no significant difference in the development of acute kidney injury, sepsis, or the use of total parenteral nutrition. Further research is needed to optimize treatment strategies and inform clinical decision-making in the IBD population.