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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Sep 5, 2022; 13(5): 67-76
Published online Sep 5, 2022. doi: 10.4292/wjgpt.v13.i5.67
Published online Sep 5, 2022. doi: 10.4292/wjgpt.v13.i5.67
Impact of epinephrine volume on further bleeding due to high-risk peptic ulcer disease in the combination therapy era
Saad Saffo, Anil Nagar, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06520, United States
Author contributions: Saffo S and Nagar A designed the study, interpreted the data and revised the manuscript; Saffo S collected and analyzed the data and wrote the initial draft of the manuscript; Nagar A is the guarantor of the study.
Supported by the National Institutes of Health , No. T32 2T32DK007356-42 .
Institutional review board statement: The study was exempted by the Institutional Review Board at Yale-New Haven Hospital (protocol number 2000029322).
Informed consent statement: Because of the retrospective and anonymous nature of this study, the need for informed consent was waived by the Institutional Review Board at Yale-New Haven Hospital.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: The data supporting the results can be made available upon request via email at the discretion of the corresponding author.
STROBE statement: The authors have read the STROBE statement checklist. They have prepared and revised the manuscript in accordance with the principles outlined in the checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Saad Saffo, MD, Academic Fellow, Section of Digestive Diseases, Yale University School of Medicine, 333 Cedar Street, 1080 LMP, New Haven, CT 06520, United States. saad.saffo@yale.edu
Received: April 13, 2022
Peer-review started: April 13, 2022
First decision: June 16, 2022
Revised: June 22, 2022
Accepted: August 1, 2022
Article in press: August 1, 2022
Published online: September 5, 2022
Processing time: 139 Days and 18.1 Hours
Peer-review started: April 13, 2022
First decision: June 16, 2022
Revised: June 22, 2022
Accepted: August 1, 2022
Article in press: August 1, 2022
Published online: September 5, 2022
Processing time: 139 Days and 18.1 Hours
Core Tip
Core Tip: To our knowledge, this is the only study specifically aimed at clarifying the impact of epinephrine volume in patients treated with combination endoscopic therapy. Our findings suggest that larger volumes of epinephrine are unlikely to improve clinical outcomes among patients who also receive thermal therapy and/or clipping.