Prospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Jul 5, 2021; 12(4): 79-89
Published online Jul 5, 2021. doi: 10.4292/wjgpt.v12.i4.79
Castor oil as booster for colon capsule endoscopy preparation reduction: A prospective pilot study and patient questionnaire
Kota Takashima, Yoriaki Komeda, Toshiharu Sakurai, Sho Masaki, Tomoyuki Nagai, Shigenaga Matsui, Satoru Hagiwara, Mamoru Takenaka, Naoshi Nishida, Hiroshi Kashida, Konosuke Nakaji, Tomohiro Watanabe, Masatoshi Kudo
Kota Takashima, Yoriaki Komeda, Toshiharu Sakurai, Sho Masaki, Tomoyuki Nagai, Shigenaga Matsui, Satoru Hagiwara, Mamoru Takenaka, Naoshi Nishida, Hiroshi Kashida, Tomohiro Watanabe, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan
Konosuke Nakaji, Division of Gastroenterology, Department of Internal Medicine, Endoscopy Center, Aishinkai Nakae Hospital, Wakayama-Shi 640-8461, Japan
Author contributions: Komeda Y contributed conceptualization, methodology, and formal analysis; Takashima K and Komeda Y contributed investigation, and wrote original draft; Watanabe T and Kudo M reviewed and edited the manuscript; Sakurai T, Masaki S, Nagai T, Matsui S, Takenaka M, Nishida N, Kashida H, and Nakaji K contributed data collection; Hagiwara S contributed statistical analysis; all authors have read and agreed to the published version of the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board of Kindai University Hospital (29-087) and the procedures were in accordance with the Declaration of Helsinki.
Clinical trial registration statement: The clinical trial is registered with University Hospital Medical Information Network, using identifier UMIN000028694. Details can be found at https://upload.umin.ac.jp/cgi-openbin/ctr_e/ctr_view.cgi?recptno=R000032809.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yoriaki Komeda, MD, PhD, Senior Lecturer, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2, Ohno-higashi, Osaka 589-8511, Japan. y-komme@mvb.biglobe.ac.jp
Received: February 2, 2021
Peer-review started: February 2, 2021
First decision: February 24, 2021
Revised: March 22, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: July 5, 2021
Processing time: 148 Days and 13.6 Hours
Core Tip

Core Tip: Castor oil, a vegetable oil collected from castor oil plant seeds, is hydrolyzed into glycerin and retinoic acid in the small intestine, stimulating bowel movement in the small intestine. Among patients treated with castor oil as a booster, the rate of capsule excretion within battery life was 88%, whereas 70% of them had a more than “good” bowel cleansing level. The questionnaire of tolerability compared with previous colonoscopy showed that 71% of patients were satisfied with the new colon capsule endoscopy procedure. Sensitivity, specificity, and diagnostic accuracy of detecting colorectal polyps (size ≥ 6 mm) were 76.9%, 75.0%, and 76.4%, respectively.