Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Jan 5, 2021; 12(1): 13-20
Published online Jan 5, 2021. doi: 10.4292/wjgpt.v12.i1.13
Published online Jan 5, 2021. doi: 10.4292/wjgpt.v12.i1.13
Increased colon transit time and faecal load in irritable bowel syndrome
Dennis Raahave, Department of Gastroenterology and Surgery, Copenhagen University North Sealand Hospital, Hilleroed 3400, Denmark
Andreas K Jensen, Faculty of Health Sciences, Section of Biostatistics, University of Copenhagen, Hilleroed 3400, Denmark
Author contributions: Raahave D and Jensen AK designed and performed the study and wrote and approved the manuscript.
Institutional review board statement: The study was reviewed and approved by the Scientific Committee, Department of Gastroenterology and Surgery, Copenhagen University North Sealand Hospital Institutional Review Board.
Informed consent statement: All patients and control persons provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dennis Raahave, DSc, MD, PhD, Consultant Physician-Scientist, Senior Researcher, Department of Gastroenterology and Surgery, Copenhagen University North Sealand Hospital, Dyrehavevej 29, Hilleroed 3400, Denmark. dr.dr@dadlnet.dk
Received: October 20, 2020
Peer-review started: October 20, 2020
First decision: October 27, 2020
Revised: November 26, 2020
Accepted: December 4, 2020
Article in press: December 4, 2020
Published online: January 5, 2021
Peer-review started: October 20, 2020
First decision: October 27, 2020
Revised: November 26, 2020
Accepted: December 4, 2020
Article in press: December 4, 2020
Published online: January 5, 2021
Core Tip
Core Tip: Patients with irritable bowel syndrome (IBS) exhibit a significant prolonged colon transit time (CTT) and greater faecal loading compared to healthy people. This finding adds to our understanding of IBS since faecal retention may lead to major symptoms like abdominal bloating and pain and defaecation disturbances. The targeted therapy was a prokinetic regime. All the more, CTT/faecal load may serve as a diagnostic procedure.