Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Jun 9, 2020; 11(2): 17-24
Published online Jun 9, 2020. doi: 10.4292/wjgpt.v11.i2.17
Gastrointestinal symptoms in acromegaly: A case control study
Nashiz Inayet, Jamal Hayat, Gul Bano, Andrew Poullis
Nashiz Inayet, Jamal Hayat, Andrew Poullis, Department of Gastroenterology, St Georges Hospital and St Georges, University of London, London SW17 0QT, United Kingdom
Gul Bano, Department of Endocrinology, St Georges Hospital and St Georges, University of London, London SW17 0QT, United Kingdom
Author contributions: Poullis A and Hayat J designed the project and reviewed the statistics and the manuscript; Bano G identified the cases and reviewed the manuscript; Inayet N collected the data, carried out the statistical analysis and wrote the manuscript.
Institutional review board statement: The study protocol was approved by the South West-Central Bristol Research Ethics Committee and NHS Health Research Authority United Kingdom.
Informed consent statement: All patients had given informed consent for this study.
Conflict-of-interest statement: The authors declare that they have no financial or personal relationship(s) that may have inappropriately influenced them in writing this article.
Data sharing statement: The questionnaire data used to support the findings of this study are available from the corresponding author upon request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Nashiz Inayet, BSc, CCST, MBBS, MD, MRCP, Doctor, Senior Lecturer, Department of Gastroenterology, St Georges Hospital and St Georges, University of London, Blackshaw Road, Tooting, London SW17 0QT, United Kingdom. n.inayet@nhs.net
Received: December 31, 2019
Peer-review started: December 31, 2019
First decision: January 19, 2020
Revised: April 25, 2020
Accepted: May 29, 2020
Article in press: May 29, 2020
Published online: June 9, 2020
Processing time: 159 Days and 11.2 Hours
Core Tip

Core tip: Irritable bowel syndrome is the commonest cause of gastrointestinal symptoms. The aetiology is thought to be multi-factorial but remains incompletely understood. Our group has previously identified that patients with connective tissue disorders have an increased incidence of functional gastrointestinal symptoms. Investigating for these symptoms in patients with acromegaly may give further insight into the pathogenesis of functional disorders and irritable bowel syndrome.