Shmuely H, Domniz N, Yahav J. Non-pharmacological treatment of Helicobacter pylori. World J Gastrointest Pharmacol Ther 2016; 7(2): 171-178 [PMID: 27158532 DOI: 10.4292/wjgpt.v7.i2.171]
Corresponding Author of This Article
Dr. Haim Shmuely, MD, Head, Department Medicine D, Kaplan Medical Center, Pasternak St., Rehovot 76100, Israel. hshmuely@zahav.net.il
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Pharmacol Ther. May 6, 2016; 7(2): 171-178 Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.171
Non-pharmacological treatment of Helicobacter pylori
Haim Shmuely, Noam Domniz, Jacob Yahav
Haim Shmuely, Jacob Yahav, Department Medicine D, Kaplan Medical Center, Rehovot 76100, Israel
Noam Domniz, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52506, Israel
Author contributions: Shmuely H, Domniz N and Yahav J contributed equally to this work.
Conflict-of-interest statement: The authors have no conflicts of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Haim Shmuely, MD, Head, Department Medicine D, Kaplan Medical Center, Pasternak St., Rehovot 76100, Israel. hshmuely@zahav.net.il
Telephone: +972-8-9441996 Fax: +972-8-9441866
Received: April 28, 2015 Peer-review started: May 6, 2015 First decision: September 8, 2015 Revised: January 13, 2016 Accepted: February 14, 2016 Article in press: February 16, 2016 Published online: May 6, 2016 Processing time: 358 Days and 1.9 Hours
Abstract
Many food and plant extracts have shown in vitro anti-Helicobacter pylori (H. pylori) activity, but are less effective in vivo. The anti-H. pylori effects of these extracts are mainly permeabilitization of the membrane, anti-adhesion, inhibition of bacterial enzymes and bacterial grown. We, herein, review treatment effects of cranberry, garlic, curcumin, ginger and pistacia gum against H. pylori in both in vitro, animal studies and in vivo studies.
Core tip: Helicobacter pylori (H. pylori) infection is difficult to eradicate and therefore, it is necessary to combine several antibiotics as well as administering a proton-pump inhibitor. Many food and plant extracts have demonstrated in vitro antibacterial activity, however, in in vivo, they are less effective. The food reviewed, herein, can be effective in preventing and/or reducing H. pylori infection. A preventive dietary approach can be very inexpensive in areas with poor health care systems.
