Published online May 5, 2022. doi: 10.4292/wjgpt.v13.i3.30
Peer-review started: March 1, 2022
First decision: April 12, 2022
Revised: April 12, 2022
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: May 5, 2022
The effect of Fuzhuan brick tea (FBT) on metabolism in obese mice is mediated by regulation of N-methyltransferase by aryl hydrocarbon receptor. The expression of the phosphatidylethanolamine N-methyltransferase gene is regulated by many transcription factors, and those specific to this effect need further investigation. Experimental animal studies have been designed to observe the effects of a single drug or the sequential effects of drugs. A washout period should be included if different drugs (e.g., antibiotics and FBT) are given to avoid or reduce additive effects or synergy. Currently, most experimental studies performed in mice used only male animals. However, experience has revealed that the results of using only male mice are very likely to have sex differences.
Core Tip: Some studies found that Fuzhuan brick tea has an effect on the gut microbiome. Many transcription factors regulate the expression of the phosphatidylethanolamine N-methyltransferase gene. Only selecting aromatic hydrocarbon acceptors for research needs to be given a sufficient basis. In germ-free mice, sex differences in metabolism were reduced, i.e., antibiotics may cause changes in the homogeneity of the mice, and if the mice are of different sexes, the gut microbiota of the mice may be different. Under the influence of antibiotics, sex differences in the microbiota may be reduced or even flattened.