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World J Gastrointest Pathophysiol. Oct 25, 2018; 9(3): 63-72
Published online Oct 25, 2018. doi: 10.4291/wjgp.v9.i3.63
Gastro-oesophageal reflux disease and eosinophilic oesophagitis: What is the relationship?
Stephanie Wong, Andrew Ruszkiewicz, Richard H Holloway, Nam Q Nguyen
Stephanie Wong, Andrew Ruszkiewicz, Richard H Holloway, Nam Q Nguyen, Discipline of Medicine, University of Adelaide, Adelaide SA 5000, Australia
Stephanie Wong, Richard H Holloway, Nam Q Nguyen, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide SA 5000, Australia
Andrew Ruszkiewicz, Anatomical Pathology, SA Pathology, Adelaide SA 5000, Australia
Author contributions: Wong S contributed to drafting of manuscript; Ruszkiewicz A, Holloway RH and Nguyen NQ contributed to critical revisions of manuscript.
Conflict-of-interest statement: There is no conflict of interest to disclose from all authors.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nam Q Nguyen, FRACP, MBBS, PhD, Associate Professor, Doctor, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide SA 5000, Australia. quocnam.nguyen@sa.gov.au
Telephone: +61-70-7442142 Fax: +61-8-7746192
Received: August 2, 2018
Peer-review started: August 3, 2018
First decision: August 24, 2018
Revised: September 17, 2018
Accepted: October 11, 2018
Article in press: October 11, 2018
Published online: October 25, 2018
Processing time: 84 Days and 3 Hours
Core Tip

Core tip: The relationship between gastro-oesophageal reflux disease and eosinophilic oesophagitis is complex as they may coexist, either interacting bidirectionally or are unrelated. This review aims to outline the differences and potential relationship between the two conditions, with specific focus on histology, immunology, pathogenesis and treatment.