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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Oct 25, 2018; 9(3): 59-62
Published online Oct 25, 2018. doi: 10.4291/wjgp.v9.i3.59
Published online Oct 25, 2018. doi: 10.4291/wjgp.v9.i3.59
Calcium and vitamin D in the serrated neoplastic pathway: Friends or foes?
Natalia García-Morales, Carla Satorres, Marco Bustamante-Balén, Gastrointestinal Endoscopy Unit, Digestive Diseases Department, La Fe Polytechnic University Hospital, Valencia 46026, Spain
Carla Satorres, Marco Bustamante-Balén, Gastrointestinal Endoscopy Research Group, IIS Hospital La Fe, Valencia 46026, Spain
Author contributions: García-Morales N drafted the initial manuscript; Satorres C performed the literature research and reviewed the manuscript draft; Bustamante-Balén M contributed to conception and design of the project and revised the article critically for important intellectual content.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Marco Bustamante-Balén, MD, PhD, Staff Physician, Gastrointestinal Endoscopy Unit, Gastrointestinal Endoscopy Research Group, La Fe University Hospital, Avda. Fernando Abril Martorell, 106, Valencia 46026, Spain. bustamante_mar@gva.es
Telephone: +34-961-2440225 Fax: +34-961-246278
Received: July 24, 2018
Peer-review started: July 24, 2018
First decision: August 8, 2018
Revised: September 11, 2018
Accepted: October 9, 2018
Article in press: October 9, 2018
Published online: October 25, 2018
Processing time: 93 Days and 11.7 Hours
Peer-review started: July 24, 2018
First decision: August 8, 2018
Revised: September 11, 2018
Accepted: October 9, 2018
Article in press: October 9, 2018
Published online: October 25, 2018
Processing time: 93 Days and 11.7 Hours
Core Tip
Core tip: Calcium and vitamin D have been shown in epidemiological studies to reduce the risk of colorectal cancer and adenomas, but the evidence regarding their effect on sessile serrated adenomas/polyps (SSA/P) is controversial - some studies showing no effect and others showing some degree of risk reduction. Recently, a randomized controlled trial with calcium and vitamin D supplements was published, concluding that the relative risk of developing a SSA/P was increased in patients taking calcium and vitamin D/calcium. In this editorial we try to place these surprising results into context, describing the limitations of this and previous studies on this topic.