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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Nov 15, 2015; 6(4): 110-119
Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.110
Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.110
New-found link between microbiota and obesity
Chandra Kanti Chakraborti, Department of Pharmacology, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela 769015, Orissa, India
Author contributions: Chakraborti CK designed research, performed research, contributed new reagents or analytic tools, analyzed data and wrote the paper.
Conflict-of-interest statement: The author has no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Chandra Kanti Chakraborti, Professor, Department of Pharmacology, Kanak Manjari Institute of Pharmaceutical Sciences, Chhend, Rourkela 769015, Orissa, India. chandrakanti_12@rediffmail.com
Telephone: +91-661-2480752 Fax: +91-661-2480752
Received: May 26, 2015
Peer-review started: May 29, 2015
First decision: June 18, 2015
Revised: September 26, 2015
Accepted: October 20, 2015
Article in press: October 27, 2015
Published online: November 15, 2015
Processing time: 174 Days and 18.1 Hours
Peer-review started: May 29, 2015
First decision: June 18, 2015
Revised: September 26, 2015
Accepted: October 20, 2015
Article in press: October 27, 2015
Published online: November 15, 2015
Processing time: 174 Days and 18.1 Hours
Core Tip
Core tip: The objective of this article is to relate gastrointestinal microbiota with obesity positively. This idea itself is most innovative. In this article, probable mechanisms involved in relating microbiota with obesity have been discussed. Its key findings are: (1) The gut microbiota play a definite role both in genesis and retardation of obesity; (2) Microbiota-derived lipopolysaccharides and short-chain fatty acids mediate the obesogenic action; (3) Fatty diet not only adds calories but also shifts microbiota compositional pattern in favour of obesity; and (4) The obesogenic actions are mediated through receptor activation, modification of cytokine and endocrine function and gene expression.